SOX11
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| Location (UCSC) | Chr 2: 5.69 – 5.7 Mb | Chr 12: 27.38 – 27.39 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.[5][6][7]
Function
This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.[7][8] Tuj1 and Tead2 are suggested as direct target of Sox11.[9][10][11]
Clinical aspect
Lymphocyte staining for SOX11 immunohistochemistry indicates mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes.[12]
Mutations in SOX11 are associated with Coffin–Siris syndrome[13] and mantle cell lymphoma.[14]
See also
- SOX genes
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176887 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063632 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8666406.
- PMID 12637543.
- ^ a b "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".
- S2CID 42742018.
- PMID 17182872.
- PMID 20596238.
- PMID 20626275.
- ^ Anna Dusenbery, M.D., Mark R. Wick, M.D. "Stains & CD markers - SOX11". Pathology Outlines.
{{cite web}}: CS1 maint: multiple names: authors list (link) Topic Completed: 1 January 2018. Minor changes: 12 August 2021 - PMID 24886874.
- PMID 28699667.
Further reading
- Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. PMID 12100890.
- Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. PMID 12194848.
- Gozé C, Poulat F, Berta P (Jun 1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Research. 21 (12): 2943. PMID 8332506.
- Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M (Jun 1998). "Cooperative function of POU proteins and SOX proteins in glial cells". The Journal of Biological Chemistry. 273 (26): 16050–7. PMID 9632656.
- Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M (Oct 1999). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Research. 6 (5): 357–60. PMID 10574465.
- Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ (May 2002). "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology. 57 (3): 201–14. S2CID 20719302.
- Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. PMID 15345747.
- Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM (Jul 2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development. 132 (13): 3045–54. PMID 15944188.
- Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F (Nov 2005). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". The Journal of Biological Chemistry. 280 (46): 38625–30. PMID 16166090.
- DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenetic and Genome Research. 112 (1–2): 176–9. S2CID 43826181.
External links
- Overview of all the structural information available in the PDB for UniProt: P35716 (Human Transcription factor SOX-11) at the PDBe-KB.
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