SOX12
SOX12 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 20: 0.33 – 0.33 Mb | Chr 2: 152.24 – 152.24 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
SOX12 is a
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000177732 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051817 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9215677.
- ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
- PMID 18505825.
- PMID 18403418.
Further reading
- Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Dev. Biol. 227 (2): 239–55. PMID 11071752.
- Weiss MA (2001). "Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition". Mol. Endocrinol. 15 (3): 353–62. PMID 11222737.
- Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. PMID 8332506.