SOX12

Source: Wikipedia, the free encyclopedia.
SOX12
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_006943

NM_011438

RefSeq (protein)

NP_008874

NP_035568

Location (UCSC)Chr 20: 0.33 – 0.33 MbChr 2: 152.24 – 152.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SOX12 is a

Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[8]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177732 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051817 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 9215677
    .
  6. ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
  7. PMID 18505825
    .
  8. .

Further reading


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