SOX8

Source: Wikipedia, the free encyclopedia.
SOX8
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_014587

NM_011447

RefSeq (protein)

NP_055402

NP_035577

Location (UCSC)Chr 16: 0.98 – 0.99 MbChr 17: 25.78 – 25.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.[5][6][7]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ATR-16 syndrome).[7]

See also

  • SOX genes

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005513 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024176 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 10662550
    .
  6. .
  7. ^ a b "Entrez Gene: SOX8 SRY (sex determining region Y)-box 8".

Further reading


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