SRD5A1
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RefSeq (protein) | |||||||||
Location (UCSC) | Chr 5: 6.63 – 6.67 Mb | Chr 13: 69.72 – 69.76 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
3-Oxo-5α-steroid 4-dehydrogenase 1 is an
Steroid 5α-reductase (EC 1.3.99.5) catalyzes, among other reactions, the conversion of
Function
The 3-oxo-5α-steroid 4-dehydrogenase 1 enzyme is involved in bile acid biosynthesis, androgen and estrogen metabolism. For instance, the enzyme catalyzes the conversion of
Regulation
ETV4 family members bind to ETS DNA-binding sites and both regulate their own expression and the transcription of a subset of genes that are dependent upon testicular luminal fluid factors, including Ggt_pr4, SRD5A1, and Gpx5.[10]
Six-month dietary vitamin E deficiency in rats resulted in a twofold increase in the mRNA level of SRD5A1 gene and a twofold decrease in the mRNA level of GCLM gene but is not directly mediated by changes in promoter DNA methylation.[11]
Insulin increases the expression of 5α-reductase type 1 mRNA via Akt signalling suggest that elevated levels of 5α-reduced androgens seen in hyperinsulinemic conditions might be explained on the basis of a stimulatory effect of insulin on 5α-reductase in granulosa cells leading to impaired follicle growth and ovulation.[12]
Clinical significance
Progression to
Expression
In humans, the protein isozyme encoded by the SRD5A1 gene is expressed in esophagus, liver, skin and 24 other tissues.[18][17]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145545 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021594 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1686016.
- ^ "Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)".
- PMID 21903862.
- PMID 22235201.
- PMID 33469028.
- PMID 16394217.
- PMID 20447326.
- PMID 20810561.
- PMID 21059865.
- PMID 19567518.
- PMID 21795608.
- ^ "What the FPKM? A review of RNA-Seq expression units". The farrago. 2 May 2014. Archived from the original on 30 December 2019. Retrieved 2 November 2020.
- ^ PMID 24309898.
- ^ "SRD5A1 steroid 5 alpha-reductase 1 - Homo sapiens (human) - expression". Archived from the original on 28 January 2024. Retrieved 8 March 2024.
Further reading
- Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW (January 1992). "Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase". The Journal of Clinical Investigation. 89 (1): 293–300. PMID 1345916.
- Andersson S, Russell DW (May 1990). "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases". Proceedings of the National Academy of Sciences of the United States of America. 87 (10): 3640–3644. PMID 2339109.
- Moore RJ, Wilson JD (February 1972). "Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate". The Journal of Biological Chemistry. 247 (3): 958–967. PMID 4400474.
- Milewich L, Kaimal V, Toews GB (May 1983). "Androstenedione metabolism in human alveolar macrophages". The Journal of Clinical Endocrinology and Metabolism. 56 (5): 920–924. PMID 6833469.
- Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW (August 1993). "Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression". The Journal of Clinical Investigation. 92 (2): 903–910. PMID 7688765.
- Antonipillai I, Wahe M, Yamamoto J, Horton R (January 1995). "Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts". Molecular and Cellular Endocrinology. 107 (1): 99–104. S2CID 21654090.
- Hirsch KS, Jones CD, Audia JE, Andersson S, McQuaid L, Stamm NB, et al. (June 1993). "LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1". Proceedings of the National Academy of Sciences of the United States of America. 90 (11): 5277–5281. PMID 8389478.
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. PMID 8619474.
- Bonkhoff H, Stein U, Aumüller G, Remberger K (October 1996). "Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas". The Prostate. 29 (4): 261–267. S2CID 29826751.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–358. PMID 9110174.
- Ellis JA, Stebbing M, Harrap SB (June 1998). "Genetic analysis of male pattern baldness and the 5alpha-reductase genes". The Journal of Investigative Dermatology. 110 (6): 849–853. PMID 9620288.
- Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW (March 1998). "Prominent sex steroid metabolism in human lymphocytes". Molecular and Cellular Endocrinology. 138 (1–2): 61–69. S2CID 20490901.
- Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, et al. (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–9548. PMID 10931946.
- Eminović I, Liović M, Prezelj J, Kocijancic A, Rozman D, Komel R (2002). "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8". Pflügers Archiv. 442 (6 Suppl 1): R187–R189. S2CID 21081236.
- Ellis JA, Wong ZY, Stebbing M, Harrap SB (December 2001). "Sex, genes and blood pressure". Clinical and Experimental Pharmacology & Physiology. 28 (12): 1053–1055. S2CID 23923031.
- Rodríguez-Dorantes M, Lizano-Soberón M, Camacho-Arroyo I, Calzada-León R, Morimoto S, Téllez-Ascencio N, Cerbón MA (March 2002). "Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes". The Journal of Steroid Biochemistry and Molecular Biology. 80 (3): 323–330. S2CID 20292300.
- Ha SJ, Kim JS, Myung JW, Lee HJ, Kim JW (April 2003). "Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia". Journal of Dermatological Science. 31 (2): 135–141. PMID 12670724.
- Habib FK, Ross M, Bayne CW, Bollina P, Grigor K, Chapman K (May 2003). "The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis". Clinical Cancer Research. 9 (5): 1815–1819. PMID 12738739.