STAT protein

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "STAT protein" – news · newspapers · books · scholar · JSTOR (August 2010) (Learn how and when to remove this template message)

STAT protein, all-alpha domain
Identifiers
Symbol	STAT_alpha
SCOP2	1bgf / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

STAT protein, DNA binding domain
Identifiers
Symbol	STAT_bind
SCOP2	1bgf / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

STAT protein, protein interaction domain
Identifiers
Symbol	STAT_int
SCOP2	1bgf / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1yvlA:2-122, 1bgfA:2-122

Dictyostelium STAT, coiled coil
SCOP2		1uur / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular

and tumor surveillance.

STAT family

The first two STAT proteins were identified in the interferon system. There are seven mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of

(ISG). In type I interferon signaling, STAT1-STAT2 heterodimer combines with IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene Factor), which binds to the ISRE (Interferon-Stimulated Response Element) promoter to induce ISG expression.

Structure

All seven STAT proteins share a common structural motif consisting of an

(NLS). Transcriptional activity and DNA association are determined by the transactivation and DNA-binding domains, respectively.

Activation

Extracellular binding of

complex.

See also

• JAK-STAT pathway
• DNA-binding protein
• STAT Inhibitors

Additional images

• 
  Key steps of the

  JAK-STAT pathway
• 
  Structure of the amino-terminal protein interaction domain of STAT-4.^[1]

References

External links

• STAT+Transcription+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Drosophila Signal-transducer and activator of transcription protein at 92E - The Interactive Fly