Salsalate
Clinical data | |
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Trade names | Disalcid, Salflex |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682880 |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
| |
ECHA InfoCard | 100.008.208 |
Chemical and physical data | |
Formula | C14H10O5 |
Molar mass | 258.229 g·mol−1 |
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Salsalate is a
Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.[2]
Mechanism of action
Relative to other NSAIDs, salsalate has a weak inhibitory effect on the
The mechanism through which salsalate is thought to reduce the production of these inflammatory chemical signals is through the inhibition of
Medical uses
Salsalate may be used for inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.[3][6]
Safety
The risk of
Research
Salsalate has been proposed for the prevention and treatment of type 2 diabetes mellitus due to its ability to lower insulin resistance associated with inflammation and may be useful in prediabetes.[3] However, the use of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has received limited study.[3]
History
This section is missing information about first known synthesis and commercialization — who decided to stick two salicylic acid molecules together?.(January 2023) |
Salsalate had been suggested as possible treatment for diabetes as early as 1876.[3][7][8]
Synthesis
References
- FDA. Retrieved 22 Oct 2023.
- ^ "Salsalate". drugs.com.
- ^ PMID 25126374.
- ^ S2CID 23674166.
- PMID 24864079.
- PMID 23801715.
- S2CID 28974642.
- ^ Ebstein W (1876). "Zur therapie des diabetes mellitus, insbesondere uber die anwendung des salicylsauren natron bei demselben". Berliner Klinische Wochenschrift. 13: 337–340.
- .
- .
- ^ DE 211403, "Verfarhen zur Darstellung einer kristallisierten Salicylosalicylsäure aus Salicylsäure oder ihrne Salzen [Process for preparing a crystallized salicylosalicylic acid from salicylic acid or its salts]", published 1909-06-25, assigned to C.F. Boehringer & Söhne
- ^ DE 214044, "Verfarhen zur Darstellung einer kristallisierten Salicylosalicylsäure [Process for preparing a crystallized salicylosalicylic acid]", published 1909-09-20, assigned to C.F. Boehringer & Söhne