Sarah Gilbert

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Sarah Gilbert (scientist)
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Vaccitech
Delta Biotechnology
Leicester Biocentre
Brewing Industry Research Foundation
Christ Church, Oxford
ThesisStudies on lipid accumulation and genetics of Rhodosporidium toruloides (1986)
Doctoral advisorColin Ratledge, Dr M. Keenan
Websitewww.jenner.ac.uk/team/sarah-gilbert Edit this at Wikidata

Dame Sarah Catherine Gilbert

Vaccitech.[2][3][4][5][6] She specialises in the development of vaccines against influenza and emerging viral pathogens.[7] She led the development and testing of the universal flu vaccine
, which underwent clinical trials in 2011.

In January 2020, she read a report on ProMED-mail about four people in China suffering from a strange kind of pneumonia of unknown origin in Wuhan.[8] Within two weeks, a vaccine had been designed at Oxford against the new pathogen, which later became known as COVID-19.[9] On 30 December 2020, the Oxford–AstraZeneca COVID-19 vaccine she co-developed with the Oxford Vaccine Group was approved for use in the UK.[10] As of January 2022, more than 2.5 billion doses of the vaccine have been released to more than 170 countries worldwide.[11]

Early life and education

Sarah Catherine Gilbert was born in

biological sciences from the University of East Anglia (UEA) in 1983.[15] While at UEA she began playing the saxophone, which she would practise in the woods around the UEA Broad so as not to disturb others in her halls.[13][16]

She moved to the

Rhodosporidium toruloides, graduating with a PhD in 1986.[17][14]

Research and career

After earning her doctoral degree, Gilbert worked as a

She was made Professor at the Jenner Institute in 2010. With the support of the Wellcome Trust, Gilbert started work on the design and creation of novel influenza vaccinations.[14] In particular, her research considers the development and preclinical testing of viral vaccinations, which embed a pathogenic protein inside a safe virus.[19][20] These viral vaccinations induce a T cell response, which can be used against viral diseases, malaria and cancer.[19]

Graphical representation of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), created by the Centers for Disease Control and Prevention, which reveals ultrastructural morphology exhibited by coronaviruses.

Gilbert was involved with the development and testing of the universal flu vaccine. Unlike conventional vaccinations, the universal flu vaccine did not stimulate the production of antibodies, but instead triggers the immune system to create T cells that are specific for influenza.[21] It makes use of one of the core proteins (nucleoprotein and matrix protein 1) inside the Influenza A virus, not the external proteins that exist on the outside coat.[22]

As the immune system weakens with age, conventional vaccinations are not effective for elderly. The universal flu vaccine does not need to be reformatted every year and stops people from needing a

Rift Valley Fever that was protective in sheep, goats, and cattle (but not proven in humans).[27]

Gilbert has been involved with the development of a new vaccination to protect against

Andrew Pollard, Teresa Lambe, Sandy Douglas, Catherine Green and Adrian Hill.[31] As with her earlier work, the COVID-19 vaccine makes use of an adenoviral vector, which stimulates an immune response against the coronavirus spike protein.[28][29] Plans were announced to start animal studies in March 2020, and recruitment began of 510 human participants for a phase I/II trial on 27 March.[32][33][34]

In April 2020, Gilbert was interviewed about the developments by

AZD1222, was being produced by AstraZeneca while phase III trials were ongoing.[38] Because of her vaccine research, Gilbert featured on The Times' 'Science Power List' in May 2020.[39]

In 2021, Gilbert and Catherine Green published Vaxxers: the inside story of the Oxford AstraZeneca vaccine and the race against the virus.[40][41]

Recognition

Gilbert was the subject of BBC Radio 4's The Life Scientific in September 2020.[42] She was also on the list of the BBC's 100 Women announced on 23 November 2020,[43] and became a senior associated research fellow at Christ Church, Oxford.[44] Gilbert was awarded the Rosalind Franklin medal for her services to science by Humanists UK at its annual Rosalind Franklin Lecture on 5 March 2021,[45] at which she delivered a lecture titled ‘Racing against the virus’. The lecture detailed the history of the science of vaccination and recounted the progress of the Oxford/AstraZeneca vaccine.[46]

In June 2021, Gilbert received a standing ovation at the 2021 Wimbledon Championships.[47] In 2021, as a role model (Barbie Shero), Sarah Gilbert had a Barbie doll made in her honour by the toy manufacturer Mattel.[48][49]

Awards

Personal life

Gilbert gave birth to triplets in 1998. Her partner gave up his career to be their primary parent.[14] As of 2020, all of the triplets are studying biochemistry at university.[12]

Selected publications

Gilbert has an h-index of 95 according to Google Scholar.[1] Her publications include:[57][58]

External links

References

  1. ^ a b Sarah Gilbert publications indexed by Google Scholar Edit this at Wikidata
  2. ^
    Wikidata Q92035270
    .
  3. ^ "Sarah Gilbert – Nuffield Department of Medicine". University of Oxford. Retrieved 10 February 2020.
  4. ^ "Professor Sarah Gilbert". University of Oxford. Archived from the original on 2 July 2020. Retrieved 10 February 2020.
  5. ^ "Professor Sarah Gilbert | University of Oxford". University of Oxford. Archived from the original on 3 August 2020. Retrieved 10 February 2020.
  6. ^ "Our Team". vaccitech.co.uk. Retrieved 28 March 2020.
  7. ^ "Professor Sarah Gilbert | Hic Vac". hic-vac.org.
  8. ISBN 978-1529369854.{{cite book}}: CS1 maint: location missing publisher (link
    )
  9. ^ McKie, Robin (4 July 2021). "Centre Court ovations, limbo-dancing grans – it's all been humbling, say Oxford vaccine creators". The Guardian. Retrieved 9 July 2021.
  10. ^ "Covid-19: Oxford-AstraZeneca coronavirus vaccine approved for use in UK". BBC News. BBC. 30 December 2020. Retrieved 30 December 2020.
  11. ^ "One year anniversary of UK deploying Oxford-AstraZeneca vaccine". gov.uk. Retrieved 4 January 2022.
  12. ^ a b Cookson, Clive (24 July 2020). "Sarah Gilbert, the researcher leading the race to a Covid-19 vaccine". Financial Times. Retrieved 25 June 2021.
  13. ^
    Newsround
    . 24 November 2020. Retrieved 28 June 2021.
  14. ^ a b c d e f Admin. "Professor Sarah Gilbert". Working for NDM. Archived from the original on 27 March 2020. Retrieved 27 March 2020.
  15. ^ "The UEA graduate leading hunt for coronavirus vaccine". Eastern Daily Press. 23 April 2020. Retrieved 20 June 2021.
  16. ^ "UEA alumni in 2020". University of East Anglia. Retrieved 28 June 2021.
  17. .
  18. ^ "Vaccine matters: Can we cure coronavirus?". Science Magazine. 12 August 2020. Retrieved 7 September 2020.
  19. ^ a b "Sarah Gilbert: Viral Vectored Vaccines — Nuffield Department of Medicine". University of Oxford. Retrieved 27 March 2020.
  20. ^ "Professor Sarah Gilbert | Hic Vac". hic-vac.org. Retrieved 27 March 2020.
  21. ^ "World-First Trial for Universal Flu Vaccine". Splice. 11 October 2017. Retrieved 27 March 2020.
  22. ^
    ISSN 0261-3077
    . Retrieved 27 March 2020.
  23. ^ "Sarah Gilbert — The Jenner Institute". jenner.ac.uk. Retrieved 27 March 2020.
  24. Wikidata Q47147430
    .
  25. ^ "New MERS Coronavirus vaccine clinical trial starts in Saudi Arabia". www.vaccitech.co.uk. 20 December 2019. Retrieved 22 March 2021.
  26. Wikidata Q64917294
    .
  27. .
  28. ^ a b "Two groups of UK scientists in race to develop coronavirus vaccine". London Evening Standard. 7 February 2020. Retrieved 27 March 2020.
  29. ^ a b "Vaccine trials among recipients of £20 million coronavirus research investment". Government of the United Kingdom. Retrieved 27 March 2020.
  30. ^ "Oxford team to begin novel coronavirus vaccine research | University of Oxford". University of Oxford. 7 February 2020. Retrieved 27 March 2020.
  31. ^ "COVID-19 Vaccine Trials | COVID-19". covid19vaccinetrial.co.uk. Retrieved 11 April 2020.
  32. ISSN 0261-3077
    . Retrieved 27 March 2020.
  33. ^ Robson, Steve (20 March 2020). "British scientists hope to start coronavirus vaccine trials next month". manchestereveningnews.co.uk. Retrieved 27 March 2020.
  34. ^ "UK scientists enrol volunteers for coronavirus vaccine trial". The Guardian. 17 March 2020.
  35. ^ "Prof Sarah Gilbert: Coronavirus vaccine trials to start within days". The Andrew Marr Show. UK. 19 April 2020. Retrieved 19 April 2020.
  36. ^ hermesauto (11 April 2020). "Coronavirus vaccine could be ready in six months, says UK scientist". The Straits Times. Retrieved 11 April 2020.
  37. ^ Stephanie Baker (30 March 2020). "How Top Scientists Are Racing to Beat the Coronavirus". Bloomberg News. Retrieved 11 April 2020.
  38. ^ Lovett, Samuel (1 September 2020). "'You just get on with it': The Oxford professor carrying the world's hopes of a coronavirus vaccine". The Independent. Retrieved 8 September 2020.
  39. ISSN 0140-0460
    . Retrieved 26 May 2020.
  40. ^ Honigsbaum, Mark (11 July 2021). "Vaxxers by Sarah Gilbert and Catherine Green; Until Proven Safe by Geoff Manaugh and Nicola Twilley – reviews". The Guardian. Retrieved 12 June 2022.
  41. S2CID 236883504
    .
  42. ^ Presenter: Jim Al-Khalili; Producer: Anna Buckley (15 September 2020). "Sarah Gilbert on developing a vaccine for Covid-19". The Life Scientific. BBC. BBC Radio 4. Retrieved 15 September 2020.
  43. ^ "BBC 100 Women 2020: Who is on the list this year?". BBC News. 23 November 2020. Retrieved 23 November 2020.
  44. ^ "e-Matters 25th February 2021". www.chch.ox.ac.uk. Retrieved 9 September 2021.
  45. ^ Gilbert, Sarah (2021). "Racing against the virus". The Rosalind Franklin Lecture. YouTube. Retrieved 7 December 2021.
  46. ^ a b "Vaccine creator Professor Sarah Gilbert delivers Rosalind Franklin Lecture to thousands". Humanists UK. Retrieved 8 March 2021.
  47. ^ Duncan, Conrad (28 June 2021). "Wimbledon crowd gives standing ovation to Oxford Covid vaccine developer". The Independent. Retrieved 29 June 2021.
  48. ^ "Vaccinologist Barbie: Prof Sarah Gilbert honoured with a doll". the Guardian. 4 August 2021.
  49. ^ Ross, Deborah (24 May 2023). "Your Sarah Gilbert doll isn't realistic, Mattel. I want a Pay Gap Barbie" – via www.thetimes.co.uk.
  50. ^ Oxford vaccine creator Professor Sarah Gilbert awarded RSA Albert Medal www.ox.ac.uk, Accessed 23 March 2021
  51. ^ "No. 63377". The London Gazette (Supplement). 12 June 2021. p. B8.
  52. ^ IT, Developed with webControl CMS by Intermark. "Katalin Karikó, Drew Weissman, Philip Felgner, Uğur Şahin, Özlem Türeci, Derrick Rossi and Sarah Gilbert - Laureates - Princess of Asturias Awards". The Princess of Asturias Foundation.
  53. ^ "Royal Society of Medicine welcomes new Honorary Fellows and medal winners". Royal Society of Medicine. 28 July 2021. Retrieved 30 August 2021.
  54. ^ "Covid vaccine co-creator Sarah Gilbert among 2022 UEA honorary graduates". Eastern Daily Press. 20 August 2021. Retrieved 30 August 2021.
  55. ^ King Faisal Prize 2023
  56. ^ "Sarah Gilbert". royalsociety.org. Retrieved 14 May 2023.
  57. ^ Sarah Gilbert publications from Europe PubMed Central
  58. ^ Publications by Sarah Gilbert at ResearchGate Edit this at Wikidata