Sazetidine A

Sazetidine A

Identifiers
IUPAC name 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol
JSmol)	Interactive image
SMILES OCCCCC#Cc1cc(cnc1)OCC2CCN2
InChI InChI=1S/C15H20N2O2/c18-8-4-2-1-3-5-13-9-15(11-16-10-13)19-12-14-6-7-17-14/h9-11,14,17-18H,1-2,4,6-8,12H2/t14-/m0/s1 Key:WONBUILDJNKYCB-AWEZNQCLSA-N
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Sazetidine A (AMOP-H-OH) is a drug which acts as a subtype selective partial agonist at α4β2 neural nicotinic acetylcholine receptors, acting as an agonist at (α4)2(β2)3 pentamers, but as an antagonist at (α4)3(β2)2 pentamers.^[1][2] It has potent analgesic effects in animal studies comparable to those of epibatidine, but with less toxicity,^[3] and also has antidepressant action.^[4]

References