Sclerotherapy

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Sclerotherapy
ICD-9-CM39.92
MeSHD015911
Sclerotherapy

Sclerotherapy (the word reflects the Greek skleros, meaning hard)[1] is a procedure used to treat blood vessel malformations (

spider veins, smaller varicose veins, hemorrhoids,[2] and hydroceles.[3]

Sclerotherapy is one method for the treatment of spider veins, varicose veins (which are also often treated with surgery,

saphenous junction, or for veins with axial reflux.[2] This is due to the emergence of more effective technologies, including laser ablation and radiofrequency, which have demonstrated superior efficacy to sclerotherapy for treatment of these veins.[6]

Historical aspects

Sclerotherapy has been used in the treatment of spider veins and occasionally varicose veins for over 150 years. Like varicose vein surgery, sclerotherapy techniques have evolved during that time. Modern techniques including ultrasonographic guidance and foam sclerotherapy are the latest developments in this evolution.

The first reported attempt at sclerotherapy was by D Zollikofer in Switzerland in 1682, who injected an acid into a vein to induce

anaesthetics
over that time, stripping became the treatment of choice.

Work continued on alternative sclerosants in the early 20th century. During that time carbolic acid and perchlorate of mercury were tried and whilst these showed some effect in obliterating varicose veins, side-effects also caused them to be abandoned. Prof. Sicard and other French doctors developed the use of sodium carbonate and then sodium salicylate during and after the First World War.[9] Quinine was also used with some effect during the early 20th century. At the time of Coppleson's book in 1929, he was advocating the use of sodium salicylate or quinine as the best choices of sclerosant.[9]

Further work on improving the technique and development of safer more effective sclerosants continued through the 1940s and 1950s. Of particular importance was the development of sodium tetradecyl sulfate (STS) in 1946, a product still widely used to this day. George Fegan in the 1960s reported treating over 13,000 patients with sclerotherapy, significantly advancing the technique by focussing on fibrosis of the vein rather than thrombosis, concentrating on controlling significant points of reflux and emphasizing the importance of compression of the treated leg.[8] The procedure became medically accepted in mainland Europe during that time. However, it was poorly understood or accepted in England or the United States, a situation that continues to this day amongst some sections of the medical community.[7]

The next major development in the evolution of sclerotherapy was the advent of

duplex ultrasonography in the 1980s and its incorporation into the practise of sclerotherapy later that decade. Knight[10] was an early advocate of this new procedure and presented it at several conferences in Europe and the United States. Thibault's article[11]
was the first on this topic to be published in a peer-reviewed journal.

The work of Cabrera[12] and Monfreaux[13] in utilising foam sclerotherapy along with Tessari's "3-way tap method" of foam production[14] further revolutionised the treatment of larger varicose veins with sclerotherapy. This has now been further modified by Whiteley and Patel[15] to use 3 non-silicone syringes for more long lasting foam.

Methods

Injecting the unwanted veins with a sclerosing solution causes the target vein to immediately shrink, and then dissolve over a period of weeks as the body naturally absorbs the treated vein. The initial "shrinkage" is caused by spasm of the muscular layer of the vein wall. The sclerosing solution damages the vein wall, causing inflammation and gradual scarring ("sclerosis") over the following weeks. The sclerosis is caused by an increase in fibroblasts in the cell wall which causes contraction of the vein. The process requires carefully assessing the strength of the sclerosing solution so it is strong enough to cause a clinically significant effect in the target vein without causing excessive damage to surrounding tissues.[16] Sclerotherapy is a non-invasive procedure taking only about 10 minutes to perform. The downtime is minimal, in comparison to an invasive varicose vein surgery.[17]

Sclerotherapy is the "gold standard" and is preferred over laser for eliminating large spider veins

reticular veins also known as feeder veins under the skin that are causing the spider veins to form, thereby making a recurrence of the spider veins in the treated area less likely. Multiple injections of dilute sclerosant are injected into the abnormal surface veins of the involved leg. The patient's leg is then compressed with either stockings or bandages that they wear usually for one week after treatment.[19]
Patients are also encouraged to walk regularly during that time. It is common practice for the patient to require at least two treatment sessions separated by several weeks to significantly improve the appearance of their leg veins.

Sclerotherapy can also be performed using microfoam sclerosants under ultrasound guidance to treat larger varicose veins, including the great and small saphenous veins.[20] After a map of the patient's varicose veins is created using ultrasound, these veins are injected whilst real-time monitoring of the injections is undertaken, also using ultrasound. The sclerosant can be observed entering the vein, and further injections performed so that all the abnormal veins are treated. Follow-up ultrasound scans are used to confirm closure of the treated veins and any residual varicose veins can be identified and treated.

Foam sclerotherapy

Foam sclerotherapy

sclerosant drugs (sodium tetradecyl sulfate, bleomycin or polidocanol) are mixed with air or a physiological gas (carbon dioxide) in a syringe or by using mechanical pumps. This increases the surface area of the drug. The foam sclerosant drug is more efficacious than the liquid one in causing sclerosis[22] (thickening of the vessel wall and sealing off the blood flow), for it does not mix with the blood in the vessel and in fact displaces it, thus avoiding dilution of the drug and causing maximal sclerosant action. It is therefore useful for longer and larger veins. Experts in foam sclerotherapy have created “tooth paste” like thick foam for their injections, which has revolutionized the non-surgical treatment of varicose veins[23] and venous malformations, including Klippel–Trénaunay syndrome.[24]

Bleomycin electrosclerotherapy

Bleomycin electrosclerotherapy consists of locally delivering the sclerosant bleomycin and applying short high voltage electrical pulses to the area to be treated, resulting in a local and temporary increased permeability of the cell membranes, increasing the intracellular concentration of bleomycin by a factor of up to several thousand.[25] Preclinical studies also indicated that electroporation in combination with bleomycin impaired the barrier function of the endothelium by interacting with the organization of the cytoskeleton and the integrity of the junctions. This can lead to extravasation, interstitial edema and a desired collapse of the vascular structures.[26] The procedure has been researched as electrochemotherapy of skin tumors since the early 1990s[27] and was first used in 2017 for vascular malformations.[28] Initial reports indicated that the use of bleomycin in combination with reversible electroporation can potentially enhance the sclerotherapy effect.[29][30] A retrospective study of 17 patients with venous malformations who did not respond to previous invasive therapies showed an average decrease in lesion volume measured on MRI images of 86% with clinical improvement in all patients after an average of 3.7 months and 1.12 sessions per patient, with a reduced dose of bleomycin and a reduced number of sessions compared to standard bleomycin sclerotherapy[31]

Clinical evaluations

A study by Kanter and Thibault in 1996 reported a 76% success rate at 24 months in treating saphenofemoral junction and great saphenous vein incompetence with STS 3% solution.[4] Padbury and Benveniste[5] found that ultrasound guided sclerotherapy was effective in controlling reflux in the small saphenous vein. Barrett et al. found that microfoam ultrasound guided sclerotherapy was "effective in treating all sizes of varicose veins with high patient satisfaction and improvement in quality of life".[32]

A

Cochrane Collaboration review comparing surgery to sclerotherapy concluded that sclerotherapy has greater benefits than surgery in the short term but surgery has greater benefits in the longer term. Sclerotherapy was better than surgery in terms of treatment success, complication rate and cost at one year, but surgery was better after five years. However, the evidence was not of very good quality and more research is needed.[34]

A Health Technology Assessment found that sclerotherapy provided less benefit than surgery, but is likely to provide a small benefit in varicose veins without reflux from the sapheno-femoral or sapheno-popliteal junctions. It did not study the relative benefits of surgery and sclerotherapy in varicose veins with junctional reflux.[35]

The European Consensus Meeting on Foam Sclerotherapy in 2003 concluded that "Foam sclerotherapy allows a skilled practitioner to treat larger veins including saphenous trunks".[36] A second European Consensus Meeting on Foam Sclerotherapy in 2006 has now been published.[37]

Complications

Complications, while rare, include

allergic reaction,[38] thrombophlebitis, skin necrosis, and hyperpigmentation or a red treatment area.[39]

If the sclerosant is injected properly into the vein, there is no damage to the surrounding skin, but if it is injected outside the vein, tissue necrosis and scarring can result.[40] Skin necrosis, whilst rare, can be cosmetically "potentially devastating", and may take months to heal. It is very rare when small amounts of dilute (<0.25%) sodium tetradecyl sulfate (STS) is used, but has been seen when higher concentrations (3%) are used. Blanching of the skin often occurs when STS is injected into arterioles (small artery branches). Telangiectatic matting, or the development of tiny red vessels, is unpredictable and usually must be treated with repeat sclerotherapy or laser.[41]

Most complications occur due to an intense inflammatory reaction to the sclerotherapy agent in the area surrounding the injected vein. In addition, there are systemic complications that are now becoming increasingly understood. These occur when the sclerosant travels through the veins to the heart, lung and brain. A recent report attributed a stroke to foam treatment,[42] although this involved the injection of an unusually large amount of foam. More recent reports have shown that bubbles from even a small amount of sclerosant foam injected into the veins quickly appear in the heart, lung and brain.[43] The significance of this is not fully understood at this point and large studies show that foam sclerotherapy is safe.[44] Sclerotherapy is fully FDA approved in the USA.[citation needed]

Contraindications include: bed rest, severe systemic diseases, poor patient understanding, needle phobia, short life expectancy, late stage cancer, known allergy to the sclerosing agent, and treatment with tamoxifen.[45]

See also

References

  1. ^ Harper, Douglas. "sclero-". Online Etymology Dictionary. Retrieved 2017-11-08.
  2. ^ a b Finkelmeier R (2005). "Sclerotherapy, Ch. 12". In Souba WW (ed.). ACS Surgery: Principles & Practice. United Kingdom: WebMD.
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  5. ^ a b Padbury A, Benveniste GL (December 2004). "Foam echosclerotherapy of the small saphenous vein". Australian and New Zealand Journal of Phlebology. 8 (1).
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  9. ^ a b c Coppleson VM (1929). Treatment of Varicose Veins by Injection (2nd ed.). Cornstalk Publishing Company.
  10. ^ Knight RM, Vin F, Zygmunt JA (1989). Davy A, Stemmer R (eds.). "Ultrasonic guidance of injection into the superficial venous system". Phlebologie. 89: 339–341.
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  12. ^ Cabrera Jr G, Garcia-Olmeda Jr C, Dominguez MA (1997). "Elargissment des limites de la schleotherapie: Nouveaux produits sclerosants". Phlebologie. 50: 181–188.
  13. ^ Monfreux A (1997). "Traitement sclerosant des trones saphen'nies et collaterales de gros calibre par le method MUS". Phlebologie. 50: 351–353.
  14. ^ Tessari L (1997). "Nouvelle technique d'obtention de la sclero-mousse". Phlebologie. 53: 129.
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  17. ^ "Articles – Sclerotherapy (Varicose Vein Treatment)". Novasans.com. Archived from the original on 2011-09-17. Retrieved 2013-03-09.
  18. ^ Sadick N, Sorhaindo L (2007). "Laser Treatment of Telangiectatic and Reticular Veins, Ch 16". In Bergan JJ (ed.). The Vein Book. p. 157.
  19. ^ "Sclerotherapy Spider Vein Treatment". 8 West Cosmetic Surgery Clinic. Retrieved 16 April 2020.
  20. ^ Thibault P (2007). "Sclerotherapy and Ultrasound-Guided Sclerotherapy". In Bergan JJ (ed.). The Vein Book.
  21. ^ "Ultrasound Guided Sclerotherapy" – via YouTube.
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