Secretor status
Secretor status refers to the presence or absence of water-soluble
Genetics
The expression of
The H antigen is required for ABO blood group antigens to be formed.[note 1] The Se gene, which encodes the enzyme α-2-L-fucosyltransferase, controls the formation of H antigen in bodily secretions. In people with the secretor genotype, the enzyme converts a precursor substance found in body fluids to the H antigen, which is then modified by the glycosyltransferases encoded by the ABO gene to produce the antigens corresponding to the person's ABO blood type. Because non-secretors cannot form H antigen in body fluids, they cannot express soluble ABO antigens.[1]: 124–6
Clinical significance
Secretor status can be determined through genotyping or through
Secretor status testing was historically used in
Prevalence
Approximately 80% of Caucasian people possess the Se gene and are secretors; the other 20% are non-secretors.
Notes
References
- ^ ISBN 978-0-8036-9462-0.
- ^ S2CID 6679013.
- ^ ISBN 978-1-119-23652-8.
- ISBN 978-0-07-182503-0.
- ^ ISBN 978-1-118-49354-0.
- ISBN 978-1-4381-0944-2.
External links
- ISBT Table of blood group antigens within systems
- Blood Groups and Red Cell Antigens National Center for Biotechnology Information (NCBI)