Senna glycoside
Clinical data | |
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Trade names | Ex-Lax, Senokot, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601112 |
License data | |
Pregnancy category |
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Routes of administration | By mouth, rectal |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Onset of action | Minutes (by rectum), 6 to 12 hours (by mouth)[3] |
Identifiers | |
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CAS Number | |
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Chemical and physical data | |
Formula | C42H38O20[4] |
Molar mass | 862.746 g·mol−1 |
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Senna glycoside, also known as sennoside or senna, is a
Common side effects of senna glycoside include abdominal cramps.
Sennosides come from the group of plants
Medical uses
Senna is used for episodic and chronic constipation though there is a lack of high-quality evidence to support its use for these purposes.[5] It may also be used to aid in the evacuation of the bowel prior to surgery or invasive rectal or colonic examinations.[12][13]
Administration
Oral senna products typically produce a bowel movement in 6 to 12 hours. Rectal suppositories can act within minutes or take up to two hours.[14]
Contraindications
According to Commission E, senna is contraindicated in cases of intestinal obstruction, acute intestinal inflammation (e.g., Crohn's disease), ulcerative colitis, appendicitis, and abdominal pain of unknown origin.[12]
Senna is considered contraindicated in people with a documented allergy to anthraquinones. Such allergies are rare and typically limited to dermatological reactions of redness and itching.[12]
Adverse effects
Adverse effects are typically limited to gastrointestinal reactions and include abdominal pain or cramps, diarrhea, nausea, and vomiting.[12]
Regular use of senna products can lead to a characteristic brown pigmentation of the internal colonic wall seen on colonoscopy. This abnormal pigmentation is known as melanosis coli.[14]
Interactions
Senna glycosides can increase digoxin toxicity in patients taking digoxin by reducing serum potassium levels, thereby enhancing the effects of digoxin.[15]
Mechanism of action
The breakdown products of senna act directly as irritants on the colonic wall to induce fluid secretion and colonic motility.[16]
Pharmacology
They are
Society and culture
Formulations
Senna is an
Brand names
Ex-Lax, Geri-kot, Perdiem Overnight Relief, Senexon, Pursennid, Senna Smooth, Senna-Gen, Senna-GRX, Senna-Lax, Senna-Tabs, Senna-Time, SennaCon, Senno, Senokot.[12]
References
- ^ a b c d e f g h i j k l American Society of Health-System Pharmacists (1 January 2008). "Senna". Drugs.com. Archived from the original on 6 September 2015. Retrieved 11 August 2015.
- ^ https://www.tga.gov.au/products/medicines/find-information-about-medicine/prescribing-medicines-pregnancy-database
- ^ "Senna(Powdered)". PubChem. U.S. National Library of Medicine.
- ^ PMID 26757467.
- ^ ISBN 9780763777685. Archivedfrom the original on 5 March 2016.
- ISBN 9783642186592. Archivedfrom the original on 5 March 2016.
- hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ a b "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Sennosides - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
- ^ "Senna; Docusate - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
- ^ a b c d e Lexicomp Online, Lexi Drugs Online, Hudson, Ohio: Lexi-Comp, Inc.; 17 April 2014.
- ^ a b Drugs.com "Senna (Professional Patient Advice)". Archived from the original on 19 April 2014. Retrieved 17 April 2014.
- ^ a b McQuaid KR (2012). "Chapter 62. Drugs Used in the Treatment of Gastrointestinal Diseases.". In Katzung BG, Masters SB, Trevor AJ (eds.). Basic & Clinical Pharmacology (12th ed.). New York, NY: McGraw-Hill. Archived from the original on 19 April 2014. Retrieved 18 April 2014.
- ^ "Senna: MedlinePlus Supplements". Archived from the original on 6 April 2015.
- ^ Sharkey KA, Wallace JL (2011). "Chapter 46. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease.". In Brunton LL, Chabner BA, Knollmann BC (eds.). Goodman & Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York, NY: McGraw-Hill. Archived from the original on 19 April 2014. Retrieved 18 April 2014.
- PMID 8234429.