Serotonin receptor antagonist
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action of
Types
5-HT2A antagonists
Antagonists of the
They include, but are not limited to:
- Cyproheptadine blocks 5-HT2A, H1 and is a mild anticholinergic.
- 5-HT1 receptor blocker. It causes retroperitoneal fibrosis and mediastinal fibrosis.[citation needed]
- H1, and A1 adrenoreceptors.
5-HT2A/2C antagonists
- adrenoreceptors.
- Risperidone antipsychotic
- Trazodone
- Nefazodone
5-HT3 antagonists
Another subclass consists of drugs selectively acting at the 5-HT3 receptors, and thus are known as 5-HT3 antagonists. They are efficacious in treating chemotherapy-induced emesis and postoperative nausea and vomiting.[1]
They include, but are not limited to:
Other 5-HT3 antagonists have been considered for use in the treatment of irritable bowel syndrome:
Also, the antidepressant mirtazapine acts as a 5-HT3 antagonist.
Non-selective 5-HT antagonists
Although some non-selective serotonin antagonists may have a particular affinity for a specific 5-HT receptor (and thus may be listed below e.g., methysergide), they still may also possess a generalised non-selective action.
They include, but are not limited to:
- Chlorpromazine
- Cyproheptadine
- Metergoline
- Methysergide
- Mianserin
- Mirtazapine
- Oxetorone
- Pizotifen
- Propranolol
- Ritanserin
- Spiperone
Antihistamines with antiserotonergic activity
- Carbinoxamine
- Cinnarizine
- Cyproheptadine
- Hydroxyzine
- Methdilazine
- Pizotifen
- Promethazine
- prophylaxis.[citation needed] Also used in the treatment of migrane.
- Oxatomide
- Oxetorone Also used in the treatment of migrane.
- Ketotifen
Others
- Fenclonine (para-chlorophenylalanine; PCPA) An inhibitor of serotonin synthesis that has been used in the treatment of carcinoid syndrome.
- ).
- Reserpine Depletes serotonin stores in the brain, heart, and many other organs and has been used in hypertension and psychosis
- Gamma-mangostin from Garcinia mangostana[4]
See also
References
External links
- Serotonin+Antagonists at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- MeSH list of agents 82012702