Serotonin releasing agent
(Redirected from
Serotonin releasing agents
)A serotonin releasing agent (SRA) is a type of drug that induces the
monoamine neurons.[1]
SSRAs have been used clinically as
appetite suppressants, and they have also been proposed as novel antidepressants and anxiolytics with the potential for a faster onset of action and superior efficacy relative to the selective serotonin reuptake inhibitors (SSRIs).[2]
A closely related type of drug is a serotonin reuptake inhibitor (SRI).
Examples and use of SRAs
4-methylaminorex
, which is an SNDRA and 5-HT2B agonist, has been reported to cause this effect as well.
Many
αMT, also tryptamines, are SNDRAs and non-selective serotonin receptor agonists that were originally thought to be monoamine oxidase inhibitors and were formerly used as antidepressants.[3]
They have since been discontinued and are now encountered solely as recreational drugs.
neuroprotective
.
List of SSRAs
Pharmaceutical drugs
- Chlorphentermine (Apsedon, Desopimon, Lucofen)
- Cloforex (Oberex) (prodrug of chlorphentermine)
- Dexfenfluramine (Redux) (enantiomer of fenfluramine)
- Etolorex (prodrug of chlorphentermine; never marketed)
- Fenfluramine (Pondimin, Fen-Phen)
- Flucetorex (related to chlorphentermine; never marketed)
- Indeloxazine (Elen, Noin) (non-selective; discontinued)
- Levofenfluramine (enantiomer of fenfluramine)
- Carbamazepine (Equetro, Epitol, and many other variations)
Research chemicals
- Amiflamine (FLA-336)
- Viqualine (PK-5078)
- 2-Methyl-3,4-methylenedioxyamphetamine(2-Methyl-MDA)
- 3-Methoxy-4-methylamphetamine (MMA)
- 3-Methyl-4,5-methylenedioxyamphetamine(5-Methyl-MDA)
- 3,4-Ethylenedioxy-N-methylamphetamine(EDMA)
- 4-Methoxyamphetamine(PMA)
- 4-Methoxy-N-ethylamphetamine(PMEA)
- 4-Methoxy-N-methylamphetamine(PMMA)
- 4-Methylthioamphetamine (4-MTA)
- 5-(2-Aminopropyl)-2,3-dihydrobenzofuran(5-APDB)
- 5-Indanyl-2-aminopropane(IAP)
- 5-Methoxy-6-methylaminoindane(MMAI)
- 5-Trifluoromethyl-2-aminoindane(TAI)
- 5,6-Methylenedioxy-2-aminoindane(MDAI)
- 5,6-Methylenedioxy-N-methyl-2-aminoindane(MDMAI)
- 6-Chloro-2-aminotetralin(6-CAT)
- 6-Tetralinyl-2-aminopropane(TAP)
- 6,7-Methylenedioxy-2-aminotetralin(MDAT)
- 6,7-Methylenedioxy-N-methyl-2-aminotetralin(MDMAT)
- N-Ethyl-5-trifluoromethyl-2-aminoindane(ETAI)
- 6-(2-aminopropil)benzofurans (6-APB)
- 5-(2-aminopropyl)benzofuran(5-APB)
See also
References
Further reading
- Nichols DE, Marona-Lewicka D, Huang X, Johnson MP (1993). "Novel serotonergic agents". Drug Design and Discovery. 9 (3–4): 299–312. PMID 8400010.
- Marona-Lewicka D, Nichols DE (December 1997). "The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats". Stress. 2 (2): 91–100. PMID 9787258.
- Scorza C, Silveira R, Nichols DE, Reyes-Parada M (July 1999). "Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action". Neuropharmacology. 38 (7): 1055–61. S2CID 13714807.
- Rothman RB, Baumann MH (April 2002). "Serotonin releasing agents. Neurochemical, therapeutic and adverse effects". Pharmacology Biochemistry and Behavior. 71 (4): 825–36. S2CID 24296122.
External links
Media related to Serotonin releasing agents at Wikimedia Commons
