Serum response factor
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Location (UCSC) | Chr 6: 43.17 – 43.18 Mb | Chr 17: 46.86 – 46.87 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Serum response factor, also known as SRF, is a transcription factor protein.[5]
Function
Serum response factor is a member of the
c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).[7][8]
SRF is important during the development of the embryo, as it has been linked to the formation of
Elk-1 may enhance or suppress expression of genes important for growth of vascular smooth muscle
.
Clinical significance
Lack of skin SRF is associated with psoriasis and other skin diseases.[13]
Interactions
Serum response factor has been shown to
interact
with:
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112658 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015605 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 20004673.
- PMID 7744019.
- PMID 8103935.
- ^ "SRF serum response factor". Entrez Gene. National Center for Biotechnology Information, National Institutes of Health.
- PMID 11983708.
- PMID 15591049.
- PMID 15647354.
- PMID 15623502.
- PMID 19307725.
- PMID 12077347.
- ^ PMID 9271374.
- PMID 10318842.
- PMID 9032301.
- ^ S2CID 9697837.
- PMID 11406578.
- PMID 11003651.
- PMID 11158291.
- S2CID 47196160.
- PMID 8106390.
- PMID 9334314.
- PMID 9584171.
- PMID 8617811.
- PMID 10082523.
- S2CID 28576187.
- PMID 10777532.
- PMID 9786846.
- PMID 11136726.
Further reading
- Esnault C, Stewart A, Gualdrini F, East P, Horswell S, Matthews N, Treisman R (May 2014). "Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts". Genes & Development. 28 (9): 943–58. PMID 24732378.
- Huh S, Song HR, Jeong GR, Jang H, Seo NH, Lee JH, Lee TH (Feb 2018). "Suppression of the ERK–SRF axis facilitates somatic cell reprogramming". Experimental & Molecular Medicine. 50 (2): e448. PMID 29472703.
- Pellegrino R, Thavamani A, Calvisi DF, Budczies J, Neumann A, Geffers R, et al. (January 2021). "Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC". Cancers. 13 (2): 199. PMID 33429878.
- Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, et al. (January 2021). "Reprogramming progressive cells display low CAG promoter activity". Stem Cells. 39 (1): 43–54. PMID 33075202.
- Kepser LJ, Khudayberdiev S, Hinojosa LS, Macchi C, Ruscica M, Marcello E, et al. (February 2021). "Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts". Scientific Reports. 11 (1): 4789. PMID 33637797.
External links
- Serum+Response+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook SRF
This article incorporates text from the United States National Library of Medicine ([1]), which is in the public domain.