Serum response factor

Source: Wikipedia, the free encyclopedia.
SRF
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_003131
NM_001292001

NM_020493

RefSeq (protein)

NP_001278930
NP_003122
NP_003122.1

NP_065239

Location (UCSC)Chr 6: 43.17 – 43.18 MbChr 17: 46.86 – 46.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serum response factor, also known as SRF, is a transcription factor protein.[5]

Function

Serum response factor is a member of the

c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).[7][8]

SRF is important during the development of the embryo, as it has been linked to the formation of

Elk-1 may enhance or suppress expression of genes important for growth of vascular smooth muscle
.

Clinical significance

Lack of skin SRF is associated with psoriasis and other skin diseases.[13]

Interactions

Serum response factor has been shown to

interact
with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112658 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015605 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. S2CID 20004673
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  8. ^ "SRF serum response factor". Entrez Gene. National Center for Biotechnology Information, National Institutes of Health.
  9. PMID 11983708
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Further reading

External links

This article incorporates text from the United States National Library of Medicine ([1]), which is in the public domain.