Sesquiterpene lactone

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Sesquiterpene lactones
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Sesquiterpene lactones (SLs) are a class of

Umbelliferae (celery, parsley, carrots) and Magnoliaceae (magnolias). A collection of colorless, lipophilic solids, SLs are a rich source of drugs.[1] They can be allergenic and toxic in grazing livestock[2] causing severe neurological problems in horses. Some are also found in corals of the order Alcyonacea
.

Types

Structures of some sesquiterpene lactones:
A: Germacranolides, B: Heliangolides, C+D: Guaianolides, E: Pseudoguaianolides, F: Hypocretenolides, G: Eudesmanolides.

Sesquiterpene lactones can be divided into several main classes including germacranolides, heliangolides, guaianolides, pseudoguaianolides, hypocretenolides, and eudesmanolides.

Examples

Artemisinin, a new, highly-effective anti-malarial compound, is a sesquiterpene lactone found in Artemisia annua. Lactucin, desoxylactucin, lactucopicrin, lactucin-15-oxalate, lactucopicrin-15-oxalate are some of the most prominent found in lettuce and spinach, giving most of the bitter taste to these crops.

One eudesmanolide, 3-oxo-5αH,8βH-eudesma-1,4(15),7(11)-trien-8,12-olide, can work with vernolic acid and other compounds in plants to reduce inflammation.[3]

Sesquiterpene lactone-containing plants

Some plants containing these compounds include:

Quorum sensing inhibitors

Sesquiterpene lactones have been found to possess the ability to inhibit quorum sensing in bacteria.[7]

References

  1. PMID 20541036
    .
  2. ^ "Sesquiterpene Lactones and their toxicity to livestock". Cornell CALS. Cornell University. Retrieved December 29, 2018.
  3. PMID 17827734
    .
  4. PMID 874606
    .
  5. PMID 16880666
    .
  6. ISBN 0-8223-1019-8
    .
  7. PMID 22925726
    .

External links
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