Sin Nombre orthohantavirus

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Sin Nombre orthohantavirus
Transmission electron micrograph of "Sin Nombre orthohantavirus"
Transmission electron micrograph of Sin Nombre orthohantavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Species:
Sin Nombre orthohantavirus
Member viruses
Synonyms
  • Four Corners virus
  • Sin Nombre hantavirus
  • Sin Nombre virus
Sin Nombre virus
SpecialtyVirology

Sin Nombre orthohantavirus (SNV) (from Spanish, meaning "without a name"), a member of the genus

hantavirus cardiopulmonary syndrome (HCPS).[1]

Discovered in 1993 near the Cañon de la Muerte on the

Navajo Reservation, it was originally named the Muerto Canyon hantavirus, in keeping with the convention for naming new pathogens.[2] However, the Navajo Nation objected to the name in 1994.[3] It was also near the Four Corners point in the United States, so the virologists then tried naming it the "Four Corners virus". The name was changed after local residents raised objections.[4]
In frustration, the virologists changed it to Sin Nombre, meaning "without a name" in Spanish.

History

It was first isolated in 1993 from rodents collected near the home of one of the initial patients with hantavirus pulmonary syndrome (HPS) in the

Bayou virus, was first isolated from the vicinity of Monroe, Louisiana.[5]

Epidemiology

SNV occurs wherever its reservoir

Peromyscus maniculatus,[6] is found, which includes essentially the entire populated area of North America, except for the far southeastern region from eastern Texas through Florida, Alaska, and the far northern reaches of Canada. SNV and HCPS are especially common in western states; peak incidences for HCPS have been reported in regions in which there is a lot of contact between humans and mice (New Mexico, Arizona) and in states with exceptionally large rural populations such as California. All of the western provinces of Canada have also reported cases. SNV can be contracted through the inhalation of virus-contaminated deer mouse excreta.[citation needed
]

While transmission from the deer mouse carrier to humans is understood to occur primarily through contact with mouse urine and feces, transmission within the vector population is believed to occur through direct contact, in contrast to the understood vector transmission for other species in the Orthohantavirus genus. [7]

The case fatality ratio of SNV-induced HCPS in the USA was reported to be about 66.7% (CDC, 1993). However, since that time the case fatality ratio has steadily declined as more mild cases came to be recognized. By 2007 the CFR had declined to about 35%.[citation needed]

Virus sequencing

As with other Orthohantavirus species, SNV has a tripartite single-stranded negative-sense RNA genome. The entire genomic sequence of SNV has subsequently been determined by using

Peromyscus maniculatus trapped in the residence of the same case), only 16 nucleotide changes were found, and none of these changes resulted in alterations in amino acid sequences of viral proteins. It had been assumed that in the process of adaptation to cell culture, selection of SNV variants which grow optimally in cell culture would occur, and selected variants would differ genetically from the parental virus. Though NMH10 and NMR11 are identical in protein sequence, nucleotide substitutions in nontranslated regions of the genome could be responsible for altered viral phenotypes, as could changes in protein glycosylation or virus membrane components.[citation needed
]

The nested

M. californicus, and Prospect Hill-like viruses in Microtus species.[citation needed
]

Virion morphology

In contrast to members of the Orthohantavirus genus endemic outside of the Americas, whose virions are predominately round or pleomorphic, SNV virions have a greater propensity for tubular and irregular virion morphologies. This finding suggests that the genus is more diverse in terms of morphology than previously assumed, which may help explain differences in epidemiology between species. Within the Sin Nombre species, morphologic variability exists between strains, with virions of an elongated phenotype associated with higher virulence. Sin Nombre virions have an average diameter of 90 nm for round particles and 85 nm for tubular particles, with an average length of 180 nm for tubular particles, making them somewhat smaller than closely related members of the genus. [8]

See also

References

  1. PMID 15109416.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link
    )
  2. PMC 6199996
    .
  3. ^ "Navajos Decry Muerto Canyon Hantavirus Site". Los Angeles Times. April 24, 1994. Retrieved 3 July 2019.
  4. ISBN 978-0-12-673050-0
    .
  5. ^ "Hantaviruses, with emphasis on Four Corners Hantavirus". Bvs.insp.mx. Archived from the original on 2013-04-20. Retrieved 2016-11-17.
  6. S2CID 19495085
    .
  7. PMID 30795592
    .
  8. PMID 31527500
    .

External links
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