Sindbis virus

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Sindbis virus
EMDB entry EMD-2374[1]
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Alsuviricetes
Order: Martellivirales
Family: Togaviridae
Genus: Alphavirus
Species:
Sindbis virus

Sindbis virus (SINV) is a member of the

Karelian fever (Russia). In humans, the symptoms include arthralgia, rash and malaise. Sindbis virus is widely and continuously found in insects and vertebrates in Eurasia, Africa, and Oceania. Clinical infection and disease in humans however has almost only been reported from Northern Europe (Finland, Sweden, Russian Karelia), where SINV is endemic and where large outbreaks occur intermittently. Cases are occasionally reported in Australia, China, and South Africa.[4]

SINV is an arbovirus, it is arthropod-borne, and it is maintained in nature by transmission between vertebrate (bird) hosts and invertebrate (mosquito) vectors. Humans are infected with Sindbis virus when bitten by an infected mosquito.

Virus physiology

Structure, genome & replication

Sindbis viruses are enveloped particles with an icosahedral

translated into the structural proteins. The viruses assemble at the host cell surfaces and acquire their envelope through budding
.

A

non-coding RNA element has been found to be essential for Sindbis virus genome replication.[5]

Recombination has been demonstrated between RNAs of Sindbis virus.[6][7] The mechanism of recombination appears to be template switching (copy choice) during RNA replication.[6][7]

See also

References

  1. PMID 23898184
    .
  2. PMID 31142666
    .
  3. ^ Kurkela S, Manni T, Vaheri A, Vapalahti O. Causative agent of Pogosta disease isolated from blood and skin lesions, Emerg Infect Dis [serial on the Internet]. Published 2004 May. (accessed 2007-10-16)
  4. ^ "Facts about Sindbis fever". European Centre for Disease Prevention and Control. Retrieved 7 September 2021.
  5. PMID 11720292
    .
  6. ^
    PMID 1579113
    .
  7. ^
    PMID 2072444
    .

External links
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