Sister Mary Joseph nodule

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In medicine, the Sister Mary Joseph nodule (sometimes Sister Mary Joseph node or Sister Mary Joseph sign) refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen.[1] Sister Mary Joseph nodules can be painful to palpation.[2]

A periumbilical mass is not always a Sister Mary Joseph nodule. Other conditions that can cause a palpable periumbilical mass include umbilical hernia, infection, and endometriosis. Medical imaging, such as abdominal ultrasound, may be used to distinguish a Sister Mary Joseph nodule from another kind of mass.[2]

Gastrointestinal malignancies account for about half of underlying sources (most commonly

lymphatics which run alongside the obliterated umbilical vein, hematogenous spread, or via remnant structures such as the falciform ligament, median umbilical ligament, or a remnant of the vitelline duct.[6] Sister Mary Joseph nodule is associated with multiple peritoneal metastases and a poor prognosis.[7][6]

History

Sister Mary Joseph Dempsey (born

eponymous term Sister Mary Joseph nodule was coined in 1949 by Hamilton Bailey.[10][2]

References

  1. ^ Smyth, Elizabeth; Cunningham, David (2014). "Pancreatic cancer". Harrison's Principles of Internal Medicine (19th ed.). McGraw-Hill Education.
  2. ^
    S2CID 38675142
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  3. PMID 17198200
  4. PMID 9490607 Free full text
  5. S2CID 89620536
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  6. ^ a b Cohen, DC. A Man With an Umbilical Ulcer. Medscape J Med. 2008;10(1):11.
  7. ^ Harrison's Principles of Internal Medicine, 16th ed. page 241
  8. ISBN 9781416062578
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  9. ISBN 9781455726646
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  10. ^ H. Bailey: Demonstration of physical signs in clinical surgery. 11th edition, Baltimore, Williams & Wilkins, 1949, p 227.
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