Small Cajal body-specific RNA

Small Cajal body-specific RNAs (scaRNAs) are a class of

The first scaRNA identified was U85.[1] It is unlike typical snoRNAs in that it is a composite C/D box and H/ACA box snoRNAs and can guide both pseudouridylation and 2′-O-methylation. Not all scaRNAs are composite C/D and H/ACA box snoRNA and most scaRNAs are structurally and functionally indistinguishable from snoRNAs, directing ribosomal RNA (rRNA) modification in the nucleolus.

Drosophila scaRNAs

Several studies identified scaRNAs in Drosophila.^{[1][2][3][4][5]} One of the studies showed that several Drosophila scaRNAs could function equally well in the nucleoplasm of mutant flies that lack Cajal bodies.^[4] Further investigation showed that scaRNA pugU6-40 targets U6 snRNA, whose modification occurs in the nucleolus not CB and that pugU1-6 and pug U2-55 guide 2 RNAs: snRNA and 28s rRNA.^[5]

Small Cajal body-specific RNA 1

In molecular biology, Small Cajal body-specific RNA 1 (also known as SCARNA1 or ACA35) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA at residue U89.

scaRNA1 is a

External links

• snoRNAbase: human H/ACA and C/D box snoRNA database
• Page for Small Cajal body-specific RNA at Rfam

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