Small intestine
Small intestine | |
---|---|
vagus[1] | |
Lymph | Intestinal lymph trunk |
Identifiers | |
Latin | intestinum tenue |
MeSH | D007421 |
TA98 | A05.6.01.001 |
TA2 | 2933 |
FMA | 7200 |
Anatomical terminology] |
Major parts of the |
Gastrointestinal tract |
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The small intestine or small bowel is an
The small intestine has three distinct regions – the
Structure
Size
The length of the small intestine can vary greatly, from as short as 3 metres (10 feet) to as long as 10.5 m (34+1⁄2 ft), also depending on the measuring technique used.[3] The typical length in a living person is 3–5 m (10–16+1⁄2 ft).[4][5] The length depends both on how tall the person is and how the length is measured.[3] Taller people generally have a longer small intestine and measurements are generally longer after death and when the bowel is empty.[3]
<2.5 cm | Non-dilated |
2.5-2.9 cm | Mildly dilated |
3–4 cm | Moderately dilated |
>4 cm | Severely dilated |
It is approximately 1.5 centimetres (5⁄8 inch) in diameter in
Parts
The small intestine is divided into three structural parts.
- The micelles. The duodenum contains Brunner's glands, which produce a mucus-rich alkaline secretion containing bicarbonate. These secretions, in combination with bicarbonate from the pancreas, neutralize the stomach acids contained in gastric chyme.
- The jejunum is the midsection of the small intestine, connecting the duodenum to the ileum. It is about 2.5 m (8 ft) long, and contains the circular folds, and intestinal villi that increase its surface area. Products of digestion (sugars, amino acids, and fatty acids) are absorbed into the bloodstream here. The suspensory muscle of duodenum marks the division between the duodenum and the jejunum.
- The ileocecal junction.[citation needed]
The jejunum and ileum are suspended in the abdominal cavity by mesentery. The mesentery is part of the peritoneum. Arteries, veins, lymph vessels and nerves travel within the mesentery.[13]
Blood supply
The small intestine receives a blood supply from the
Microanatomy
The three sections of the small intestine look similar to each other at a microscopic level, but there are some important differences. The parts of the intestine are as follows:
Layer | Duodenum | Jejunum | Ileum |
---|---|---|---|
Serosa |
1st part serosa, 2nd–4th adventitia | Normal | Normal |
Muscularis externa |
Longitudinal and circular layers, with Auerbach's (myenteric) plexus in between |
Same as duodenum | Same as duodenum |
Submucosa | Meissner's (submucosal) plexus |
No BG | No BG |
Mucosa: muscularis mucosae |
Normal | Normal | Normal |
Mucosa: lamina propria | No PP | No PP | Peyer's patches
|
Mucosa: intestinal epithelium | goblet cells, Paneth cells |
Similar to intestinal villus is long |
Similar to duodenum, but the intestinal villus is short |
Gene and protein expression
About 20,000 protein coding genes are expressed in human cells and 70% of these genes are expressed in the normal duodenum.[15][16] Some 300 of these genes are more specifically expressed in the duodenum with very few genes expressed only in the small intestine. The corresponding specific proteins are expressed in glandular cells of the mucosa, such as fatty acid binding protein FABP6. Most of the more specifically expressed genes in the small intestine are also expressed in the duodenum, for example FABP2 and the DEFA6 protein expressed in secretory granules of Paneth cells.[17]
Development
The small intestine develops from the midgut of the primitive gut tube.[18] By the fifth week of embryological life, the ileum begins to grow longer at a very fast rate, forming a U-shaped fold called the primary intestinal loop. The loop grows so fast in length that it outgrows the abdomen and protrudes through the umbilicus. By week 10, the loop retracts back into the abdomen. Between weeks six and ten the small intestine rotates anticlockwise, as viewed from the front of the embryo. It rotates a further 180 degrees after it has moved back into the abdomen. This process creates the twisted shape of the large intestine.[18]
-
First stage of the development of the intestinal canal and the peritoneum, seen from the side (diagrammatic). From colon 1 the ascending and transverse colon will be formed and from colon 2 the descending and sigmoid colons and the rectum.
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Second stage of development of the intestinal canal and peritoneum, seen from in front (diagrammatic). The liver has been removed and the two layers of the ventral mesogastrium (lesser omentum) have been cut. The vessels are represented in black and the peritoneum in the reddish tint.
-
Third state of the development of the intestinal canal and peritoneum, seen from in front (diagrammatic). The mode of preparation is the same as in Fig 400
Function
Food from the stomach is allowed into the duodenum through the pylorus by a muscle called the pyloric sphincter.
Digestion
The small intestine is where most chemical digestion takes place. Many of the digestive enzymes that act in the small intestine are secreted by the pancreas and liver and enter the small intestine via the pancreatic duct. Pancreatic enzymes and bile from the gallbladder enter the small intestine in response to the hormone cholecystokinin, which is produced in the response to the presence of nutrients. Secretin, another hormone produced in the small intestine, causes additional effects on the pancreas, where it promotes the release of bicarbonate into the duodenum in order to neutralize the potentially harmful acid coming from the stomach.
The three major classes of nutrients that undergo digestion are proteins, lipids (fats) and carbohydrates:
- Proteins are degraded into small peptides and amino acids before absorption.[19] Chemical breakdown begins in the stomach and continues in the small intestine. Proteolytic enzymes, including trypsin and chymotrypsin, are secreted by the pancreas and cleave proteins into smaller peptides. Carboxypeptidase, which is a pancreatic brush border enzyme, splits one amino acid at a time. Aminopeptidase and dipeptidase free the end amino acid products.
- Lipids (fats) are degraded into gall bladder. Bile salts attach to triglycerides to help emulsifythem, which aids access by pancreatic lipase. This occurs because the lipase is water-soluble but the fatty triglycerides are hydrophobic and tend to orient towards each other and away from the watery intestinal surroundings. The bile salts emulsify the triglycerides in the watery surroundings until the lipase can break them into the smaller components that are able to enter the villi for absorption.
- Some carbohydrates are degraded into simple sugars, or intestinal bacteria. Brush border enzymes take over from there. The most important brush border enzymes are dextrinase and glucoamylase, which further break down oligosaccharides. Other brush border enzymes are maltase, sucrase and lactase. Lactase is absent in some adult humans and, for them, lactose (a disaccharide), as well as most polysaccharides, is not digested in the small intestine. Some carbohydrates, such as cellulose, are not digested at all, despite being made of multiple glucoseunits. This is because the cellulose is made out of beta-glucose, making the inter-monosaccharidal bindings different from the ones present in starch, which consists of alpha-glucose. Humans lack the enzyme for splitting the beta-glucose-bonds, something reserved for herbivores and bacteria from the large intestine.
Absorption
Digested food is now able to pass into the blood vessels in the wall of the intestine through either
Each villus has a network of capillaries and fine lymphatic vessels called lacteals close to its surface. The epithelial cells of the villi transport nutrients from the lumen of the intestine into these capillaries (amino acids and carbohydrates) and lacteals (lipids). The absorbed substances are transported via the blood vessels to different organs of the body where they are used to build complex substances such as the proteins required by our body. The material that remains undigested and unabsorbed passes into the large intestine.
Absorption of the majority of nutrients takes place in the jejunum, with the following notable exceptions:
- Iron is absorbed in the duodenum.
- Folate (Vitamin B9) is absorbed in the duodenum and jejunum.
- terminal ileum. Vitamin B12 will only be absorbed by the ileum after binding to a protein known as intrinsic factor.
- Water is absorbed by osmosis and lipids by passive diffusion throughout the small intestine.
- co-transport
- Fructose is absorbed by facilitated diffusion.
Immunological
The small intestine supports the body's
Clinical significance
The small intestine is a complex organ, and as such, there are a very large number of possible conditions that may affect the function of the small bowel. A few of them are listed below, some of which are common, with up to 10% of people being affected at some time in their lives, while others are vanishingly rare.
- Small intestine obstruction or obstructive disorders
- Meconium ileus
- Paralytic ileus
- Volvulus
- Hernia
- Intussusception
- Adhesions
- Obstruction from external pressure
- Obstruction by masses in the lumen (foreign bodies, bezoar, gallstones)
- Infectious diseases
- Giardiasis
- Ascariasis
- Tropical sprue
- Tape worm (Diphyllobothrium latum, Taenia solium, Hymenolepis nana)
- Hookworm (e.g. Necator americanus, Ancylostoma duodenale)
- Nematodes (e.g. Ascaris lumbricoides)
- Other Protozoa (e.g. Cryptosporidium parvum, Cyclospora, Microsporidia, Entamoeba histolytica)
- Bacterial infections
- Enterotoxigenic Escherichia coli
- Salmonella enterica
- Campylobacter
- Shigella
- Yersinia
- Pseudomembranous colitis)
- Mycobacterium avium paratuberculosis, disseminated Mycobacterium tuberculosis)
- Whipple's disease
- Vibrio (cholera)
- Enteric (typhoid) fever (Salmonella enterica var. typhii) and paratyphoid fever
- Bacillus cereus
- Clostridium perfringens (gas gangrene)
- Viral infections
- Rotavirus
- Norovirus
- Astrovirus
- Adenovirus
- Calicivirus
- Neoplasms (cancers)
- Adenocarcinoma
- Carcinoid
- Gastrointestinal stromal tumor (GIST)
- Lymphoma
- Sarcoma
- Leiomyoma
- Metastatic tumors, especially SCLC or melanoma
- Small intestine cancer
- Developmental, congenital or genetic conditions
- Duodenal (intestinal) atresia
- Hirschsprung's disease
- Meckel's diverticulum
- Pyloric stenosis
- Pancreas divisum
- Ectopic pancreas
- Enteric duplication cyst
- Situs inversus
- Cystic fibrosis
- Malrotation
- Persistent urachus
- Omphalocele
- Gastroschisis
- Disaccharidase (lactase) deficiencies
- Primary bile acid malabsorption
- Gardner syndrome
- Familial adenomatous polyposis syndrome (FAP)
- Other conditions
- Crohn's disease, and the more general inflammatory bowel disease
- immunosuppressed
- Coeliac disease (sprue or non-tropical sprue)
- Mesenteric ischemia
- Embolus or thrombus of the superior mesenteric artery or the superior mesenteric vein
- Arteriovenous malformation
- Gastric dumping syndrome
- Irritable bowel syndrome
- Duodenal (peptic) ulcers
- Gastrointestinal perforation
- Hyperthyroidism
- Diverticulitis
- Radiation enterocolitis
- Mesenteric cysts
- PeritonealInfection
- Sclerosing retroperitonitis
- Small intestinal bacterial overgrowth
- Endometriosis
Other animals
The small intestine is found in all tetrapods and also in teleosts, although its form and length vary enormously between species. In teleosts, it is relatively short, typically around one and a half times the length of the fish's body. It commonly has a number of pyloric caeca, small pouch-like structures along its length that help to increase the overall surface area of the organ for digesting food. There is no ileocaecal valve in teleosts, with the boundary between the small intestine and the rectum being marked only by the end of the digestive epithelium.[22]
In tetrapods, the
The boundaries between the duodenum, jejunum, and ileum are somewhat vague even in humans, and such distinctions are either ignored when discussing the anatomy of other animals, or are essentially arbitrary.[22]
There is no small intestine as such in non-teleost fish, such as sharks, sturgeons, and lungfish. Instead, the digestive part of the gut forms a spiral intestine, connecting the stomach to the rectum. In this type of gut, the intestine itself is relatively straight but has a long fold running along the inner surface in a spiral fashion, sometimes for dozens of turns. This valve greatly increases both the surface area and the effective length of the intestine. The lining of the spiral intestine is similar to that of the small intestine in teleosts and non-mammalian tetrapods.[22]
In lampreys, the spiral valve is extremely small, possibly because their diet requires little digestion. Hagfish have no spiral valve at all, with digestion occurring for almost the entire length of the intestine, which is not subdivided into different regions.[22]
Society and culture
In
Additional images
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Small intestine in situ, greater omentum folded upwards.
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Tissue layers (mucosa, submucosa & muscularis)
References
- ^ Nosek, Thomas M. "Section 6/6ch2/s6ch2_30". Essentials of Human Physiology. Archived from the original on 2016-03-24.
- ^ human body | Britannica.com
- ^ ISBN 9781498720809.
- ISBN 978-1-118-34500-9.
..its length is about 3m in a living person and about 6.5m in a cadaver due to loss of smooth muscle tone after death.
- ISBN 978-0-7020-5230-9.
..and has a mean length of 5 metres (3 - 8.5 metres) when measured intraoperatively in the living adult (Tietelbaum et al 2013).
- PMID 17331829.
- ^ Debora Duro, Daniel Kamin (2007). "Overview of short bowel syndrome and intestinal transplantation". Colombia Médica. 38 (1).
- ^ a b Ali Nawaz Khan (2016-09-22). "Small-Bowel Obstruction Imaging". Medscape. Retrieved 2017-02-07.
- ^ "Abdominal X-ray - Abnormal bowel gas pattern". radiologymasterclass.co.uk. Retrieved 2017-02-07.
- PMID 8273687.
- S2CID 11094705.
- ISBN 978-0-8089-2306-0.
- ISBN 978-0-8089-2306-0.
- ^ ISBN 978-0-8089-2306-0.
- ^ "The human proteome in small intestine - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-26.
- S2CID 802377.
- S2CID 21302849.
- ^ ISBN 9780443068119.
- PMID 4604970.
- ^ "Intestinal immune cells play an unexpected role in immune surveillance of the bloodstream". Massachusetts General Hospital. 13 December 2012. Archived from the original on 16 October 2018. Retrieved 28 August 2013.
- PMID 18474643.
- ^ ISBN 978-0-03-910284-5.
- )
Bibliography
- Sherwood, Lauralee (2006). Fundamentals of physiology: a human perspective (Third ed.). Florence, KY: Cengage Learning. p. 768. ISBN 978-0-534-46697-8.
- Solomon et al. (2002) Biology Sixth Edition, Brooks-Cole/Thomson Learning ISBN 0-03-033503-5
- Townsend et al. (2004) Sabiston Textbook of Surgery, Elsevier ISBN 0-7216-0409-9
- Thomson A, Drozdowski L, Iordache C, Thomson B, Vermeire S, Clandinin M, Wild G (2003). "Small bowel review: Normal physiology, part 1". Dig Dis Sci. 48 (8): 1546–64. S2CID 37494914.
- Thomson A, Drozdowski L, Iordache C, Thomson B, Vermeire S, Clandinin M, Wild G (2003). "Small bowel review: Normal physiology, part 2". Dig Dis Sci. 48 (8): 1565–81. S2CID 42442830.