Sodium aurothiomalate

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Sodium aurothiomalate
Clinical data
Trade namesMyocrisin
AHFS/Drugs.comMultum Consumer Information
License data
Pregnancy
category
  • AU: B2
Intramuscular
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: Discontinued
Pharmacokinetic data
Protein bindingHigh[1]
Elimination half-life6-25 days[1]
ExcretionUrine (60-90%), faeces (10-40%)[1]
Identifiers
  • Sodium 2-(auriosulfanyl)-3-carboxypropanoate
JSmol)
  • [Au+].[Na+].[O-]C(=O)C([S-])CC(=O)O
  • InChI=1S/C4H6O4S.Au.Na/c5-3(6)1-2(9)4(7)8;;/h2,9H,1H2,(H,5,6)(H,7,8);;/q;2*+1/p-2 checkY
  • Key:LTEMOXGFFHXNNS-UHFFFAOYSA-L checkY
  (verify)

Sodium aurothiomalate (

gold compound that is used for its immunosuppressive anti-rheumatic effects.[2][3] Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern medicine.[4]

Medical uses

It is primarily given once or twice weekly by intramuscular injection for moderate-severe rheumatoid arthritis. It has also proven to be effective in treating tuberculosis.[5]

Adverse effects

Its most common side effects are digestive (mostly

cholestatic jaundice, peripheral neuropathy, Guillain–Barré syndrome, encephalopathy, encephalitis and photosensitivity.[6]

Pharmacology

Its precise mechanism of action is unknown but is known that it inhibits the synthesis of

phagocytic cells and inhibits class II major histocompatibility complex-peptide interactions.[4] It is also known that it inhibits the following enzymes:[4][7]

History of use

Reports of favorable use of the compound were published in France in 1929 by Jacques Forestier.[9] The use of gold salts was then a controversial treatment and was not immediately accepted by the international community. Success was found in the treatment of Raoul Dufy's joint pain by the use of gold salts in 1940; "(the treatment) brought in a few weeks such a spectacular sense of healing, that Dufy ... boasted of again having the ability to catch a tram on the move."[10]

Along with aurothioglucose, sodium aurothiomalate was discontinued in the United States, leaving auranofin as the only gold salt remaining on the U.S. market.[when?][citation needed]

References

  1. ^ a b c "aurothiomalate, sodium, Myochrysine (gold sodium thiomalate) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 March 2014.
  2. PMID 9783766
    .
  3. S2CID 20169992
    .
  4. ^
    S2CID 808858
    .
  5. S2CID 37436710
    .
  6. ^
    ISBN 978-0-9805790-9-3
    .
  7. PMID 21755088
    .
  8. S2CID 5213201
    .
  9. PMID 16694848
    .
  10. ^ Lamboley C (December 6, 2010). "Deux rhumatisants au soleil du Midi : Renoir et Dufy" [Two rheumatic in the Midi sun: Renoir and Dufy] (PDF). Académie des Sciences et Lettres de Montpellier (in French). Montpellier. Retrieved July 7, 2015.
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