Sodium orthovanadate

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Sodium orthovanadate
Names
IUPAC name
Sodium vanadate(V)
Other names
Sodium vanadium oxide
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ECHA InfoCard
 100.033.883 Edit this at Wikidata
RTECS number
  • YW1120000
UNII
  • InChI=1S/3Na.4O.V/q3*+1;;3*-1;
  • [O-] [V](=O)([O-])[O-].[Na+].[Na+].[Na+]
Properties
Na3VO4
Molar mass 183.908 g/mol
Appearance white powder
Density 2.16 g/cm3, solid
Melting point 858 °C (1,576 °F; 1,131 K)
22.17 g/100 mL
Solubility insoluble in ethanol
Structure
cubic
Thermochemistry
164.8 J/mol K
190 J/mol K
Std enthalpy of
formation
(ΔfH⦵298)
 −1757 kJ/mol
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Harmful.
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
3
0
0
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
330 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sodium orthovanadate is the inorganic compound with the chemical formula Na3V O4. It forms a dihydrate Na3VO4·2H2O. Sodium orthovanadate is a salt of the VO3−4 oxyanion. It is a colorless, water-soluble solid.[2]

Synthesis and structure

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:

V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2O

The salt features tetrahedral VO3−4 anion centers linked to octahedral Na+ cation sites.[3]

Condensation equilibria

Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by

decavanadate is formed.[5]

Biochemistry

Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates.[6][7] It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases,[8] and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).[9]

Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes

decavanadate into the active inhibitor, monovanadate.[8]

References

  1. ^ "Archived copy". Archived from the original on 2016-03-04. Retrieved 2017-09-28.{{cite web}}: CS1 maint: archived copy as title (link)
  2. ISBN 978-0-08-037941-8
    .
  3. doi:10.1107/S0108270187093120
    .
  4. ISBN 9780123739193
    .
  5. doi:10.1002/9780470132586.ch15
    .
  6. PMID 22693688
    .
  7. ISBN 978-0-08-097774-4
    .
  8. ^ a b "Sodium orthovanadate" (PDF). Sigma-Aldrich. Retrieved September 7, 2018.
  9. ^ Biolabs, New England. "Sodium Orthovanadate (Vanadate) | NEB". www.neb.com. Retrieved 2018-09-07.

See also

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