Sp100 nuclear antigen
| SP100 nuclear antigen | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SP100 | ||||||
Chr. 2 q37.1 | |||||||
| |||||||
Sp100 nuclear antigen is an
mitogens affect the expression of the Sp100 autoantigen. Cells grown in the presence of interferons
(α, β, and γ) revealed an increase both in size and number of the Sp100 protein-containing nuclear dots and increase the protein concentration.
This raises "the question whether cytokine-mediated increase of Sp100 protein expression plays a role in induction of anti-Sp100 autoantibodies."[2]
Sp100 and nuclear dots
Two proteins, Sp100 and promyelocytic leukemia (
SUMO-1, that also interact with nuclear pore complex factors also interact with these two proteins.[4] In addition Sp100 interacts with a chromatin binding protein, HP1 alpha.[5]
Sp100 splicoforms
Some Sp100 variants contain a domain similar to two interferon-inducible nuclear
high mobility group 1 (HMG1) protein sequence as a domain. Both major classes of Sp100 splice variant proteins localize in part to nuclear dots/PML bodies and other nuclear domains.[6]