Specific granule
(Redirected from
Specific granules
)Specific granules are secretory
vesicles found exclusively in cells of the immune system called granulocytes
.
It is sometimes described as applying specifically to neutrophils,[1] and sometimes the term is applied to other types of cells.[2]
These
antimicrobial peptides, that are released by a process called degranulation
following activation of the granulocyte by an immune stimulus.
Specific granules are also known as "secondary granules".[3]
Contents
Examples of cytotoxic molecule stored by specific granules in different granulocytes include:
- Neutrophil: alkaline phosphatase, lactoferrin, lysozyme, NADPH oxidase
- Eosinophil: cathepsin, major basic protein
- cytotoxic)
Clinical significance
A
References
- ^ "Definition: specific granule from Online Medical Dictionary".
- PMID 7334549.
- ISBN 978-0-7817-6507-7. Retrieved 10 November 2010.
- ^ Online Mendelian Inheritance in Man (OMIM): SPECIFIC GRANULE DEFICIENCY; SGD - 245480
External links
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