Sticky platelet syndrome

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Sticky platelet syndrome
SpecialtyHematology

Sticky platelet syndrome (SPS) is a heritable disorder of

OMIM
.

It can present in conjunction with protein S deficiency and factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.

SPS has not been widely studied[9] and is not widely known.[10]

Signs and symptoms

Symptoms are related to hypercoagulability,

arterial thrombosis,[9] myocardial infarction, angina, and stroke.[1]

Cause

The syndrome is believed to be hereditary.[11]

Diagnosis

SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry, platelet stickiness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[12] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.[citation needed]

Treatment

Treatment usually consists of a daily low dose (80–100 mg) of

Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.[citation needed
]

References

  1. ^
    PMID 10548069
    .
  2. PMID 12627663
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  3. S2CID 42202617
    .
  4. PMID 2465231
    .
  5. PMID 17532753
    .
  6. ISBN 978-0-521-83953-2
    .
  7. ISBN 978-0-521-87082-5
    .
  8. S2CID 35754773
    .
  9. ^
    S2CID 246905075
    .
  10. PMID 29850310
    .
  11. ^ Bick RL (April 2006). "Hereditary and acquired thrombophilic disorders". Clinical and Applied Thrombosis/Hemostasis. 12 (2): 125–135.
    S2CID 42478313
    .
  12. PMID 12565719
    .
  13. PMID 10548069
    .
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