Subacute cutaneous lupus erythematosus
| Subacute cutaneous lupus erythematosus | |
|---|---|
| Other names | SCLE |
| Specialty | Dermatology  |
Subacute cutaneous lupus erythematosus (SCLE ) is a clinically distinct subset of cases of
Characteristically the lesions appear in sun-exposed areas such as the vee of the
Therapy generally involves sun avoidance and protection and topical
Lesions of SCLE may have an annular (shaped like a ring) configuration, with raised red borders and central clearing.[4][5]
Signs and symptoms
The lesions of systemic lupus erythematosus are characterized by their distribution, which can be either annular with central clearing or papulosquamous. The lesions normally heal without atrophy or scarring, and these two forms can happen at the same time. While telangiectasia or hypopigmentation may occur, most patients' skin returns to normal.[6] Serologic abnormalities, musculoskeletal complaints, and mild illness are common in patients with SCLE.[7] SCLE typically avoids the face and is more common in sun-exposed areas such as the neck, shoulders, chest, and extensor surfaces of the arms.[6]
Causes
The etiology of systemic lupus erythematosus is not well understood. Sunlight exposure is the traditional precipitating factor in patients with immune dysregulation and an aberrant milieu of genetic predisposition. There have also been reports of drug-induced SCLE. Angiotensin-converting enzyme inhibitors, anticonvulsants, beta-blockers, and immune modulators, such as TNF alpha inhibitors, are frequently used medications that have been linked to SCLE. Case reports of SCLE developing in cancers have been published.[6]
Diagnosis
Like other forms of
See also
- Lupus erythematosus
- List of cutaneous conditions
- List of human leukocyte antigen alleles associated with cutaneous conditions
References
- ISBN 0-7216-2921-0.
- ^ a b Burkhalter NW, McKenzie JT, Lane JE (2009). "Subacute cutaneous lupus erythematosus". Consultant. 49 (3).
- PMID 9782534.
- ISBN 978-1-4160-2999-1.
- PMID 533284.
- ^ PMID 32119441. Retrieved February 15, 2024.
- ISSN 0003-987X.
Further reading
- Lowe, G.; Henderson, C.L.; Grau, R.H.; Hansen, C.B.; Sontheimer, R.D. (2011). "A systematic review of drug-induced subacute cutaneous lupus erythematosus: Systematic review of drug-induced SCLE". British Journal of Dermatology. .
- Sontheimer, Richard D. (1989). "Subacute Cutaneous Lupus Erythematosus: A Decade's Perspective". Medical Clinics of North America. 73 (5). Elsevier BV: 1073–1090. ISSN 0025-7125.