Submucosa

Source: Wikipedia, the free encyclopedia.
Submucosa
longitudinal muscle
Serosa or Adventitia
Endoscopy and radial endoscopic ultrasound images of submucosal tumour in mid-esophagus. The submucosa is seen as a dark ring on the ultrasound image.
Details
Identifiers
Latintela submucosa
TA98A05.3.01.028
A05.4.01.014
A05.5.01.026
A05.6.01.008
A05.7.01.005
A06.4.02.028
A08.3.01.022
TA22857, 2891, 2913, 2939, 2967, 3221, 3234, 3419
FMA85391
Anatomical terminology]

The submucosa (or tela submucosa) is a thin layer of

organs of the gastrointestinal, respiratory, and genitourinary tracts. It is the layer of dense irregular connective tissue that supports the mucosa (mucous membrane) and joins it to the muscular layer, the bulk of overlying smooth muscle
(fibers running circularly within layer of longitudinal muscle).

The submucosa (sub- + mucosa) is to a mucous membrane what the subserosa (sub- + serosa) is to a serous membrane.

Structure

postganglionic nerve fibers that supply the muscularis mucosae. Histologically, the wall of the alimentary canal shows four distinct layers (from the lumen moving out): mucosa, submucosa, muscularis externa, and either a serous membrane or an adventitia
.

In the

submucosal glands that secrete mucus
.

Clinical significance

Identification of the submucosa plays an important role in diagnostic and therapeutic

fibre-optic cameras are used to perform procedures on the gastrointestinal tract. Abnormalities of the submucosa, such as gastrointestinal stromal tumors
, usually show integrity of the mucosal surface.

The submucosa is also identified in

epinephrine into the submucosa is imperative in the safe removal of certain polyps
.

Endoscopic mucosal resection involves removal of the mucosal layer, and in order to be done safely, a submucosal injection of dye is performed to ensure integrity at the beginning of the procedure.

Female uterine submucosal layers are liable to develop fibroids during pregnancy and are often excised upon discovery.[1]

Small intestinal submucosa

Small intestinal submucosa (SIS) is submucosal

transplanted structural material in several clinical applications, typically biologic meshes. They have low immunogenicity. Some uses under investigation include a scaffold for intervertebral disc regeneration.[2][3]

Unlike other scaffold materials, the resorbable SIS extracellular matrix (SIS-ECM) scaffold is replaced by well-organized host tissues, including differentiated skeletal muscle.[4]

History

A scientific article published in March 2018[5] proposed a revision of the anatomical definition of the submucosa. They first saw a non compact tissue which should be submucosa using a technology called endomicroscopy. They hypothesised that the submucosa was not compact as it was previously seen on histological analysis but form a reticular pattern. To confirm their findings, they performed fixed samples of bile duct into a freezing media in order to conserve the shape of the submucosa. They then performed a histological analysis and with several staining techniques, they described the submucosa as a network of collagenous bands separating open, formerly fluid-filled spaces. Theses spaces are bordered by fibroblast-like cells CD34 positive. However, these cells are devoid of ultrastructural features indicative of endothelial differentiation, including pinocytotic vesicles and Weibel-Palade bodies.

Additional images

  • Stomach.
    Stomach.
  • Section of the human esophagus. Moderately magnified.
    Section of the human esophagus. Moderately magnified.
  • Vertical section of bladder wall.
    Vertical section of bladder wall.
  • General structure of the gut wall showing the submucosa.
    General structure of the gut wall showing the submucosa.

References

  1. ^ "What is the submucosa and why is it important? - Submucosa". Archived from the original on 2019-06-23. Retrieved 2018-07-25.
  2. PMID 16998356
    .
  3. PMID 15967902
    .
  4. PMID 11922734
    .
  5. ^ Benias, P., Wells, R., Sackey-Aboagye, B., Klavan, H., Reidy, J., Buonocore, D., Miranda, M., Kornacki, S., Wayne, M., Carr-Locke, D. and Theise, N. (2018). Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Scientific Reports, 8(1).
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