Systems medicine
Systems medicine is an interdisciplinary field of study that looks at the systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems medicine draws on systems science and systems biology, and considers complex interactions within the human body in light of a patient's genomics, behavior and environment.[1]
The earliest uses of the term systems medicine appeared in 1992, in an article on systems medicine and pharmacology by T. Kamada.[2]
An important topic in systems medicine and systems biomedicine is the development of computational models that describe disease progression and the effect of therapeutic interventions.[3] [4]
More recent approaches include the redefinition of disease phenotypes based on common mechanisms rather than symptoms. These provide then therapeutic targets including network pharmacology[5] and drug repurposing.[6] Since 2018, there is a dedicated scientific journal, Systems Medicine.[7]
Fundamental schools of systems medicine
Essentially, the issues dealt with by systems medicine can be addressed in two basic ways, molecular (MSM) and organismal systems medicine (OSM):[8][9]
Molecular systems medicine (MSM)
This approach relies on
Organismal systems medicine (OSM)
This branch of systems medicine, going back to the traditions of
A common challenge for both schools is the translation between the molecular and the organismal level. This can be achieved e.g. by affine subspace mapping and sensitivity analysis, but also requires some preparative steps on both ends of the epistemic gap.[9]
=== Systems Medicine Education ===
This article may require cleanup to meet Wikipedia's quality standards. The specific problem is: low quality, country not specified, poor punctuation, inappropriately promotes a single organisation / individual. (February 2024) |
Georgetown University is the first in the Nation to launch a MS program in Systems Medicine. It has developed a rigorous curriculum, The programs have been developed and led by Dr. Sona Vasudevan, PhD.
https://systemsmedicine.georgetown.edu/
List of research groups
Country | University / Institute | Department / Center / Program / Network | Participants |
---|---|---|---|
Austria | University of Vienna | Centre for Organismal Systems Biology (COSB)[10] | |
Ireland | Royal College of Surgeons in Ireland | Medical Systems Biology[11] | |
Luxembourg | Luxembourg Centre for Systems Biomedicine
|
Computational Biology group[12] | |
Netherlands | Eindhoven University of Technology (TU/e) | Department of Biomedical Engineering, Computational Biology Group (CBio)[13] | Natal van Riel |
USA | Institute for Systems Biology (ISB) | Leroy Hood, Alan Aderem, Ruedi Aebersold | |
Germany | Helmholtz Association of German Research Centres
|
Department of Systems Immunology[14] | Esteban Hernandez-Vargas |
Netherlands | Utrecht University | Laboratory of Translational Immunology[15]
Utrecht Center for Quantitative Immunology[16] Pharmacology and Personalised Medicine[17] |
Prof. Timothy Radstake,
Dr. Aridaman Pandit Prof. Harald H.H.W. Schmidt |
Israel | Weizmann Institute of Science | Department of Molecular Cell Biology[18]
Systems Medicine course[19] |
Uri Alon[20][21] |
Norway | Haukeland University Hospital | Neuro-SysMed[22] | Kjell-Morten Myhr, Charalampos Tzoulis |
See also
References
- S2CID 219774.
- PMID 1599879.
- S2CID 21941015.
- PMID 23935478.
- S2CID 40005254.
- PMID 29423274.
- .
- S2CID 202718643.
- ^ PMID 33855036.
- ^ "Organismal Systems Biology". lifesciences.univie.ac.at. Retrieved 17 April 2021.
- ^ "Medical Systems Biology". Royal College of Surgeons in Ireland.
- ^ "Computational Biology group". Luxembourg Centre for Systems Biomedicine. 16 March 2024.
- ^ "Computational Biology Group". Eindhoven University of Technology.
- ^ "Systems Biology at the Helmholtz Centre for Infectious Diseases, Braunschweig". Helmholtz Centre for Infection Research.
- ^ "Radstake TRDJ".
- ^ "Utrecht Center for Quantitative Immunology".
- ^ "Pharmacology & Personalised Medicine | Pharmacology & Personalised Medicine". ppm.mumc.maastrichtuniversity.nl. Retrieved 2017-02-02.
- ^ "Molecular Cell Biology, Weizmann Institute of Science". www.weizmann.ac.il. Retrieved 2019-05-05.
- ^ "Systems Medicine course 2019 | Uri Alon". www.weizmann.ac.il. Retrieved 2019-05-05.
- PMID 27875241.
- PMID 28652282.
- ^ Norges første forskningssenter for klinisk behandling tildelt Archived April 17, 2019, at the Wayback Machine Annonsering 11/2018.