TFMFly

Source: Wikipedia, the free encyclopedia.
TFMFly
Legal status
Legal status
Identifiers
  • (2R)-1-[4-(trifluoromethyl)-2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran-8-yl]propan-2-amine
JSmol)
  • c13OCCc3c(C(F)(F)F)c2OCCc2c1CC(C)N
  • InChI=1S/C14H16F3NO2/c1-7(18)6-10-8-2-4-20-13(8)11(14(15,16)17)9-3-5-19-12(9)10/h7H,2-6,18H2,1H3/t7-/m1/s1
  • Key:KMWGSFWAZUVTCM-SSDOTTSWSA-N
  (verify)

TFMFly is a compound related to

5HT2A serotonin receptor subtype, and is a chiral compound with the more active (R) enantiomer having a Ki of 0.12 nM at the human 5-HT2A receptor.[2] While the fully aromatic benzodifurans such as Bromo-DragonFLY generally have higher binding affinity than saturated compounds like 2C-B-FLY,[3] the saturated compounds have higher efficacy as agonists.[4]

Legal Status

TFMFly is illegal in Latvia.[5]

See also

References

  1. ProQuest 304838368
    .
  2. S2CID 24005602
    .
  3. PMID 11300881
    .
  4. ^ Heim R. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts (Ph.D. thesis) (in German). Freien Universität Berlin.
  5. ^ "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" [Regulations on Narcotic Drugs, Psychotropic Substances and Precursors Controlled in Latvia] (in Latvian). Ministry of Health of the Republic of Latvia.
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