TGF-beta receptor family
| Ser/Thr protein kinase, TGFB receptor | |
|---|---|
| Identifiers | |
| Symbol | TGFb_receptor |
SCOP2 | 1B6C / SCOPe / SUPFAM |
| Membranome | 1216 |
The transforming growth factor beta (TGFβ) receptors are a
NODAL.[1]
TGFβ family receptors
TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed the
activin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.[2][3] In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.[4] The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.[5]
Type I
| Transforming growth factor beta type I GS-motif | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TGF_beta_GS | ||||||||
| Pfam | PF08515 | ||||||||
| InterPro | IPR003605 | ||||||||
| |||||||||
- ALK1(ACVRL1)
- ALK2(ACVR1A)
- ALK3(BMPR1A)
- ALK4(ACVR1B)
- ALK5(TGFβR1)
- ALK6(BMPR1B)
- ALK7(ACVR1C)
Type II
Type III
Unlike the Type I and II receptors which are kinases, TGFBR3 has a
- TGFβR3 (β-glycan)
References
- ^ "Prosite Documentation PDOC00223". Archived from the original on 2011-05-25. Retrieved 2006-07-01.
- ISBN 978-1-4200-0716-9.
- ISBN 978-1-4614-1991-4.
- S2CID 54397586.
- PMID 11583628.
- PMID 2592419.
- PMID 1556106.