Toll-like receptor 3
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| Location (UCSC) | Chr 4: 186.07 – 186.09 Mb | Chr 8: 45.85 – 45.86 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Toll-like receptor 3 (TLR3) also known as CD283 (
Function
TLR3 is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (
TLR3 recognizes double-stranded
TLR3 displays a protective role in mouse models of atherosclerosis,[10] and activation of TLR3 signaling is associated with ischemic preconditioning-induced protection against brain ischemia and attenuation of reactive astrogliosis.[11][12] Furthermore, TLR3 activation has been shown to promote hair follicle regeneration in skin wound healing.[13] In addition, TLR3 activators show effects on human vascular cells.[10]
Structure
The structure of TLR3 was reported in June 2005 by researchers at
Despite being a glycoprotein, TLR3 crystallises readily – a prerequisite for structural analysis by x-ray crystallography.
Ligands
- Antagonists
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164342 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031639 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9435236.
- ^ PMID 18029230.
- ^ "Entrez Gene: toll-like receptor 3".
- ISBN 978-0-7020-4089-4.
- S2CID 4346537.
- ^ PMID 21220319.
- PMID 24914679.
- PMID 26494128.
- PMID 26253200.
- S2CID 4962727.
Further reading
- Lien E, Ingalls RR (January 2002). "Toll-like receptors". Critical Care Medicine. 30 (1 Suppl): S1-11. PMID 11782555.
- Wang PF, Fang H, Chen J, Lin S, Liu Y, Xiong XY, Wang YC, Xiong RP, Lv FL, Wang J, Yang QW (May 2014). "Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3". Journal of Immunology. 192 (10): 4783–94. PMID 24729619.
- Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, Lu Q, Wang J (November 2015). "TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia". CNS Neuroscience & Therapeutics. 21 (11): 905–13. PMID 26494128.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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