Herpesvirus entry mediator
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TNFRSF14
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| Location (UCSC) | Chr 1: 2.56 – 2.57 Mb | Chr 4: 155.01 – 155.01 Mb | |||||||
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Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human
Nomenclature
This protein was originally known as herpesvirus entry mediator A (HveA);
HveC are structurally unrelated proteins of the immunoglobulin superfamily. It is also known as CD270 in the cluster of differentiation
classification. Moreover, it is also referred to as ATAR (another TRAF-associated receptor).
Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response.[7]
In melanocytic cells TNFRSF14 gene expression may be regulated by MITF.[9]
Interactions
TNFRSF14 has been shown to
Clinical relevance
Mutations in this gene have been recurrently been associated to cases of diffuse large B-cell lymphoma[14][15] and pediatric-type follicular lymphoma.[16]
This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism.[7]
References
- ^ a b c ENSG00000157873 GRCh38: Ensembl release 89: ENSG00000273936, ENSG00000157873 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042333 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 14626053.
- PMID 9162061.
- ^ a b c d "TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) ]". Gene. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 5 January 2024.
- ISBN 978-0-7817-6519-0.
- PMID 19067971.
- ^ PMID 9153189.
- ^ PMID 9162022.
- PMID 11390428.
- PMID 10318773.
- PMID 21796119.
- PMID 22343534.
- PMID 28277421.
Further reading
- Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry. 272 (21): 13471–4. PMID 9153189.
- Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. PMID 9162022.
- Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF (January 1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21–30. PMID 9462508.
- Lee CH, Chinpaisal C, Wei LN (November 1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Molecular and Cellular Biology. 18 (11): 6745–55. PMID 9774688.
- Kelly K, Manos E, Jensen G, Nadauld L, Jones DA (February 2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Research. 60 (4): 1021–7. PMID 10706119.
- Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, Wu J (June 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". The Journal of Clinical Investigation. 107 (11): 1459–68. PMID 11390428.
- Franco PJ, Farooqui M, Seto E, Wei LN (August 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. PMID 11463856.
- Carfí A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC (July 2001). "Herpes simplex virus glycoprotein D bound to the human receptor HveA". Molecular Cell. 8 (1): 169–79. PMID 11511370.
- Bobik A, Kalinina N (December 2001). "Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (12): 1873–5. PMID 11742858.
- Struyf F, Posavad CM, Keyaerts E, Van Ranst M, Corey L, Spear PG (January 2002). "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". The Journal of Infectious Diseases. 185 (1): 36–44. PMID 11756979.
- Carfí A, Gong H, Lou H, Willis SH, Cohen GH, Eisenberg RJ, Wiley DC (May 2002). "Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA". Acta Crystallographica Section D. 58 (Pt 5): 836–8. PMID 11976496.
- Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (September 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. PMID 12093804.
- Gill RM, Ni J, Hunt JS (December 2002). "Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes". The American Journal of Pathology. 161 (6): 2011–7. PMID 12466117.
- Bender FC, Whitbeck JC, Ponce de Leon M, Lou H, Eisenberg RJ, Cohen GH (September 2003). "Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry". Journal of Virology. 77 (17): 9542–52. PMID 12915568.
- Jung HW, La SJ, Kim JY, Heo SK, Kim JY, Wang S, Kim KK, Lee KM, Cho HR, Lee HW, Kwon B, Kim BS, Kwon BS (December 2003). "High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases". Experimental & Molecular Medicine. 35 (6): 501–8. PMID 14749527.
- Krummenacher C, Baribaud F, Ponce de Leon M, Baribaud I, Whitbeck JC, Xu R, Cohen GH, Eisenberg RJ (May 2004). "Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus". Virology. 322 (2): 286–99. PMID 15110526.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.