TNF receptor superfamily
| TNFR/NGFR cysteine-rich region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Membranome | 6 | ||||||||
| |||||||||
The tumor necrosis factor receptor superfamily (TNFRSF) is a
leukocytes.[4]
The term death receptor refers to those members of the TNF receptor superfamily that contain a death domain, such as TNFR1, Fas receptor, DR4 and DR5.[4] They were named after the fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well.[5]
In the strict sense, the term TNF receptor is often used to refer to the archetypal members of the superfamily, namely TNFR1 and
TNFR2
, which recognize TNF-alpha.
Members
There are 27 family members, numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter.[2]
| Type | Protein (member #) | Synonyms | Gene | Ligand(s) |
|---|---|---|---|---|
| 1 | Tumor necrosis factor receptor 1 (1A) | CD120a | TNFRSF1A | TNF (cachectin)
|
| Tumor necrosis factor receptor 2 (1B) | CD120b | TNFRSF1B | ||
| 3 | Lymphotoxin beta receptor (3) | CD18 | LTBR | Lymphotoxin beta (TNF-C) |
| 4 | OX40 (4) | CD134 | TNFRSF4 | OX40L
|
| 5 | CD40 (5) | Bp50 | CD40 | CD154 |
| 6 | Fas receptor (6) | Apo-1, CD95 | FAS | FasL
|
| Decoy receptor 3 (6B) | TR6, M68 | TNFRSF6B | FasL, TL1A
| |
| 7 | CD27 (7) | S152, Tp55 | CD27 | Siva
|
| 8 | CD30 (8) | Ki-1, TNR8 | TNFRSF8 | CD153 |
| 9 | 4-1BB (9) | CD137 | TNFRSF9 | 4-1BB ligand
|
| 10 | Death receptor 4 (10A) | TRAILR1, Apo-2, CD261 | TNFRSF10A | TRAIL |
| Death receptor 5 (10B) | TRAILR2, CD262 | TNFRSF10B | ||
| Decoy receptor 1 (10C) | TRAILR3, LIT, TRID, CD263 | TNFRSF10C | ||
| Decoy receptor 2 (10D) | TRAILR4, TRUNDD, CD264 | TNFRSF10D | ||
| 11 | RANK (11A) | CD265 | TNFRSF11A | RANKL |
| Osteoprotegerin (11B) | OCIF, TR1 | TNFRSF11B | ||
| 12 | TWEAK receptor (12A) | Fn14, CD266 | TNFRSF12A | TWEAK |
| 13 | TACI (13B) | IGAD2, CD267 | TNFRSF13B | CAMLG
|
| BAFF receptor (13C) | CD268 | TNFRSF13C | BAFF | |
| 14 | Herpesvirus entry mediator (14) | ATAR, TR2, CD270 | TNFRSF14 | LIGHT |
| 16 | Nerve growth factor receptor (16)
|
p75NTR, CD271 | NGFR | |
| 17 | B-cell maturation antigen (17) | TNFRSF13A, CD269, BCMA | TNFRSF17 | BAFF |
| 18 | Glucocorticoid-induced TNFR-related (18) | AITR, CD357 | TNFRSF18 | GITR ligand |
| 19 | TROY (19) | TAJ, TRADE | TNFRSF19 | unknown |
| 21 | Death receptor 6 (21) | CD358 | TNFRSF21 | |
| 25 | Death receptor 3 (25) | Apo-3, TRAMP, LARD, WS-1 | TNFRSF25 | TL1A |
| 27 | Ectodysplasin A2 receptor (27)
|
XEDAR | EDA2R | EDA-A2
|
References
Further reading
- Kavurma MM, Tan NY, Bennett MR (2008). "Death receptors and their ligands in atherosclerosis". Arterioscler Thromb Vasc Biol. 28 (10): 1694–702. PMID 18669890.
- Hatano, E. (2007). "Tumor necrosis factor signaling in hepatocyte apoptosis". J Gastroenterol Hepatol. 22: S43–44. PMID 17567463.
External links
- Tumor+Necrosis+Factor+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)