TRA (gene)

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.^[2][3][4] It contributes the alpha chain to the larger TCR protein (T-cell receptor).

References

Further reading

• Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86.
  PMID 1303175
  .
• Suzuki CK, Bonifacino JS, Lin AY, et al. (1991). "Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP". J. Cell Biol. 114 (2): 189–205.
  PMID 1649196
  .
• Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94.
  PMID 1827423
  .
• Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305.
  S2CID 2180901
  .
• Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073–83.
  PMID 2546634
  .
• Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 (2): 389–96.
  S2CID 22340836
  .
• Yanagi Y, Chan A, Chin B, et al. (1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3430–4.
  PMID 3873654
  .
• Sim GK, Yagüe J, Nelson J, et al. (1985). "Primary structure of human T-cell receptor alpha-chain". Nature. 312 (5996): 771–5.
  S2CID 4350315
  .
• Kearse KP, Roberts JL, Singer A (1995). "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes". Immunity. 2 (4): 391–9.
  PMID 7719941
  .
• Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains". Eur. J. Immunol. 24 (1): 84–92.
  S2CID 85378646
  .
• Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro". Genes Dev. 11 (5): 629–39.
  PMID 9119227
  .
• San José E, Sahuquillo AG, Bragado R, Alarcón B (1998). "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model". Eur. J. Immunol. 28 (1): 12–21.
  S2CID 85318973
  .
• Ding YH, Smith KJ, Garboczi DN, et al. (1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids". Immunity. 8 (4): 403–11.
  PMID 9586631
  .
• Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84.
  PMID 11390434
  .
• Shelton JG, Gülland S, Nicolson K, et al. (2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits". Mol. Immunol. 38 (4): 259–65.
  PMID 11566319
  .
• Pietra G, Romagnani C, Falco M, et al. (2002). "The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition". Eur. J. Immunol. 31 (12): 3687–93.
  PMID 11745389
  .
• Hennecke J, Wiley DC (2002). "Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity". J. Exp. Med. 195 (5): 571–81.
  PMID 11877480
  .
• García P, Llano M, de Heredia AB, et al. (2002). "Human T cell receptor-mediated recognition of HLA-E". Eur. J. Immunol. 32 (4): 936–44.
  PMID 11920559
  .

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