TRPP
TRPP (transient receptor potential polycystic) is a family of transient receptor potential ion channels which when mutated can cause polycystic kidney disease.
Subcategories
TRPP subunits can be divided into two subcategories depending on structural similarity.
Polycystic Kidney Disease 1 (PKD1)-Like Group
The first group, polycystic kidney disease 1 (PKD1)-like, contains
polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal adhesive domains that are important for cell-cell contact.[1] This group of subunits also contain a large extracellular domain with numerous polycystin motifs. These motifs are of unknown function and are located between the S6 and S7 segments. The large intracellular C-terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex.[2]
Polycystic Kidney Disease 2 (PKD2)-Like Group
This group of TRPP members (previously known as TRPP2-like) are: TRPP1 (previously known as TRPP2 or PKD2), TRPP2 (previously known as TRPP3 or PKDL2), and TRPP3 (previously known as TRPP5 or polycystin-L2).G proteins by PKD1.[2]
Genes
- Group 1: polycystic kidney disease 1 (PKD1) like proteins
- Group 2: polycystic kidney disease 2 (PKD2) like proteins
See also
References
- ISBN 978-94-007-0264-6
- ^ PMID 17237345.
- ^ *"Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
External links
- TRPP+Cation+Channels at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- "Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels.