TRPP

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TRPP (transient receptor potential polycystic) is a family of transient receptor potential ion channels which when mutated can cause polycystic kidney disease.

Subcategories

TRPP subunits can be divided into two subcategories depending on structural similarity.

Polycystic Kidney Disease 1 (PKD1)-Like Group

The first group, polycystic kidney disease 1 (PKD1)-like, contains

polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal adhesive domains that are important for cell-cell contact.[1] This group of subunits also contain a large extracellular domain with numerous polycystin motifs. These motifs are of unknown function and are located between the S6 and S7 segments. The large intracellular C-terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex.[2]

Polycystic Kidney Disease 2 (PKD2)-Like Group

This group of TRPP members (previously known as TRPP2-like) are: TRPP1 (previously known as TRPP2 or PKD2), TRPP2 (previously known as TRPP3 or PKDL2), and TRPP3 (previously known as TRPP5 or polycystin-L2).

G proteins by PKD1.[2]

Genes

See also

References

  1. ^ .
  2. ^ *"Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

External links

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