Tacalcitol

Source: Wikipedia, the free encyclopedia.
Tacalcitol
Clinical data
Other names(1α,24R)-1,24-Dihydroxyvitamin D3
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Topical
ATC code
Identifiers
  • (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
JSmol)
  • O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C
  • InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ☒N
  • Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic

vitamin D3 analog.[1]
Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

It is on the World Health Organization's List of Essential Medicines.[2]

Mechanism

Tacalcitol reduces excessive cell turnover in the epidermis by interacting with

keratinocytes.[3][4]

Uses

It is usually prescribed by a general practitioner or dermatologist for the treatment of

chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover.[1]
It is available as an ointment or lotion.

It has also been used for

References