Tachykinin peptides
| Tachykinin family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| OPM superfamily | 143 | ||||||||
| OPM protein | 1myu | ||||||||
| |||||||||
Tachykinin peptides are one of the largest families of
Tachykinins
The two human tachykinin genes are called
TAC3 encodes neurokinin B.[8]
The best known tachykinin is Substance P.
Receptors
There are three known
- NK1: SP > NKA > NKB
- NK2: NKA > NKB > SP
- NK3: NKB > NKA > SP
Antagonists of neurokinin-1 (NK1) receptors (NK1 receptor antagonists), through which substance P acts, have been proposed to belong to a new class of antidepressants,[9]
Tachykinin peptides are also involved in inflammation, and tachykinin receptor antagonists have been researched for use in treating inflammatory conditions such as asthma and irritable bowel syndrome.[15] [16] [17] The main use for which these antagonist drugs have been applied so far, however, is as antiemetics, in both human and veterinary medicine.[18] [19]
Examples of tachykinin antagonists include:[20]
Subfamilies
References
- S2CID 42266413.
- ^ PMID 1695945.
- PMID 3284438.
- S2CID 25935155.
- PMID 1324401.
- S2CID 33412235.
- ^ Online Mendelian Inheritance in Man (OMIM): TAC1 - 162320
- ^ Online Mendelian Inheritance in Man (OMIM): TAC3 - 162330
- PMID 17786860.
- PMID 15155133.
- S2CID 15134994.
- S2CID 21490514.
- S2CID 13270787.
- PMID 16918327.
- PMID 16918328.
- PMID 16918330.
- S2CID 22707433.
- S2CID 21437603.
- PMID 18471143.
- PMID 16918326.
External links
- Tachykinins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)