Talk:5-HTTLPR

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why would the S/S polymorphism be associated with depression if it infact causes more serotonin in the synaptic cleft? It acts like an SSRI? What is the mechanism of this relationship?

Technically beyond the scope of a wikipedia talk page, but the "serotonergic model" of depression is not foolproof. Other neurotransmitters also take part. For example, enhancing dopamine can also successfully treat depression. — Preceding unsigned comment added by 2602:306:BDED:C710:3C2D:E249:B47E:5501 (talk) 15:13, 16 November 2013 (UTC)[reply]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Choi.kel.

Above undated message substituted from

The penultimate sentence (specifically "we would expect that those replication studies which are closest in design to the original are the most likely to replicate—instead we find the opposite.") appears to be ripped straight out of an analysis or research article based on usage of "we" as a personal pronoun. The tone and style is inappropriate for a Wikipedia article. I would edit it, but I am not sufficiently versed in the subject to do so. Thor214 (talk) 22:57, 29 April 2017 (UTC)[reply]

I find it to be a glaring omission that two SNPs (rs25531 and rs25532) of the SLC6A4 gene are specifically mentioned as being associated with 5-HTTLPR, but the reference sequence for 5-HTTLPR itself (rs4795541) is not provided anywhere in an article dedicated to 5-HTTLPR (rs4795541)!

https://www.snpedia.com/index.php/Rs4795541

47.42.126.4 (talk) 17:41, 11 May 2017 (UTC)Parttime5HTTLPRresearcher[reply]

I plan on adding a section on Insomnia and how there are studies exploring the 5-HTTPLR genotype's association with it. There are many studies that suggest the genotype plays a role in mood, temperament affective disorders, and sleep quality. Choi.kel (talk) 18:16, 8 August 2017 (UTC)[reply]