Talk:Acetylcholinesterase inhibitor

Page contents not supported in other languages.
Source: Wikipedia, the free encyclopedia.
WikiProject iconMedicine Mid‑importance
WikiProject iconThis article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.
MidThis article has been rated as Mid-importance on the project's importance scale.

Antidotes?

Why doesn't the article mention

2-16 15:03, 30 May 2007 (UTC)[reply
]

noradrenaline is even of lower relevance, since it is only a symptomatic treatment of circulatory collapse, which is not a core symptom of AChEI intoxication; the only real "advisable" antidote for all AChEIs is atropine, given by i.v. titration. It is the only agent, that does help in all AChEI intoxications (though the most severe intoxications are often lethal despite high-dose atropine), regardless of their severity or casual noxis, i.e. one could not make a manifest AChEI intoxication worse by administration of atropine, as opposed to e.g. oximes. However, this article deals not so much with AChEI toxicology, it's only a brief summary of mechanisms and agents; the respective articles nerve agent and insecticide provide specific information about causal and symptomatic treatment of intoxications.--84.163.96.19 20:25, 29 September 2007 (UTC)[reply
]

Mechanism

I was reading http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-us-brain-power-drugs and it mentioned cholinesterase inhibitors as a coming big thing in nootropics, but I was a little puzzled.

Choline supplements of various stripes have been available for a very long time, and I understood that they worked by encouraging choline->acetylcholine, and acetylcholinesterase works by destroying acetylcholine; so wouldn't the end-goal of choline supplementation and acetylcholinesterase inhibition be the same: a rise in acetylcholine? Why then the interest? --129.49.7.125 (talk) 21:33, 1 October 2009 (UTC)[reply]

Review

Interesting review [1] --

talk · contribs · email) 15:37, 30 April 2011 (UTC)[reply
]

Link broken? (access attempt failed April 28, 2013)
Ocdnctx (talk) 18:31, 28 April 2013 (UTC)[reply]

Supplements inhibiting Acetylcholinesterase

Supplements inhibiting Acetylcholinesterase include

Bacopa

Acetyl-L-Carnitine

Such supplements, as well as

Huperzine
etc., share many of the side effects of pharmaceutical acetylcholinesterase inhibitors.

Ocdnctx (talk) 18:29, 28 April 2013 (UTC)[reply]

effects

I think it is worth having an effects section of this article. The side effects covers unintended consequences, possibly reflecting a a smaller or chronic dose. And uses section is the practical realization of intended effects. But the direct consequences of intended use are not listed here. This would be the consequences to a prey organism of a spider bite (paralysis) or the use of a chemical weapon. Dbsseven (talk) 19:58, 14 March 2018 (UTC)[reply]

partial inhibition?

Are there any examples of acetylcholinesterase partial inhibitors known?

(An enzyme partial inhibitor is a substance that reduces the speed at which the enzyme catalyzes the reaction of its substrate, but it does not disable the enzyme completely even at high concentration. This means, an ACHE partial inhibitor would slow down cholinergic transmission, but not as extremely as a complete inhibitor.) --79.240.205.49 (talk) 00:30, 9 August 2018 (UTC)[reply]