Talk:Acetylcholinesterase inhibitor
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Antidotes?
Why doesn't the article mention
- noradrenaline is even of lower relevance, since it is only a symptomatic treatment of circulatory collapse, which is not a core symptom of AChEI intoxication; the only real "advisable" antidote for all AChEIs is atropine, given by i.v. titration. It is the only agent, that does help in all AChEI intoxications (though the most severe intoxications are often lethal despite high-dose atropine), regardless of their severity or casual noxis, i.e. one could not make a manifest AChEI intoxication worse by administration of atropine, as opposed to e.g. oximes. However, this article deals not so much with AChEI toxicology, it's only a brief summary of mechanisms and agents; the respective articles nerve agent and insecticide provide specific information about causal and symptomatic treatment of intoxications.--84.163.96.19 20:25, 29 September 2007 (UTC)]
Mechanism
I was reading http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-us-brain-power-drugs and it mentioned cholinesterase inhibitors as a coming big thing in nootropics, but I was a little puzzled.
Choline supplements of various stripes have been available for a very long time, and I understood that they worked by encouraging choline->acetylcholine, and acetylcholinesterase works by destroying acetylcholine; so wouldn't the end-goal of choline supplementation and acetylcholinesterase inhibition be the same: a rise in acetylcholine? Why then the interest? --129.49.7.125 (talk) 21:33, 1 October 2009 (UTC)
Review
Interesting review [1] --
]Supplements inhibiting Acetylcholinesterase
Supplements inhibiting Acetylcholinesterase include
Such supplements, as well as
Ocdnctx (talk) 18:29, 28 April 2013 (UTC)
effects
I think it is worth having an effects section of this article. The side effects covers unintended consequences, possibly reflecting a a smaller or chronic dose. And uses section is the practical realization of intended effects. But the direct consequences of intended use are not listed here. This would be the consequences to a prey organism of a spider bite (paralysis) or the use of a chemical weapon. Dbsseven (talk) 19:58, 14 March 2018 (UTC)
partial inhibition?
Are there any examples of acetylcholinesterase partial inhibitors known?
(An enzyme partial inhibitor is a substance that reduces the speed at which the enzyme catalyzes the reaction of its substrate, but it does not disable the enzyme completely even at high concentration. This means, an ACHE partial inhibitor would slow down cholinergic transmission, but not as extremely as a complete inhibitor.) --79.240.205.49 (talk) 00:30, 9 August 2018 (UTC)