Temefos

Source: Wikipedia, the free encyclopedia.
Temefos
Names
Preferred IUPAC name
O-[4-({4-[(Dimethoxyphosphorothioyl)oxy]phenyl}sulfanyl)phenyl] O,O-dimethyl phosphorothioate
Other names
[4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]-
dimethoxy-sulfanylidene-phosphorane
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.020.175 Edit this at Wikidata
KEGG
MeSH Temefos
UNII
  • InChI=1S/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3 checkY
    Key: WWJZWCUNLNYYAU-UHFFFAOYSA-N checkY
  • InChI=1/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3
    Key: WWJZWCUNLNYYAU-UHFFFAOYAC
  • S=P(OC)(OC)Oc2ccc(Sc1ccc(OP(=S)(OC)OC)cc1)cc2
Properties
C16H20O6P2S3
Molar mass 466.46 g·mol−1
Appearance white, crystalline solid[1]
Density 1.32 g cm−3
Melting point 30 °C (86 °F; 303 K)
Boiling point 120–125[1] °C (248–257 °F; 393–398 K) (decomposes)
insoluble[1]
Vapor pressure 0.00000007 mmHg (20°C)[1]
Hazards
NIOSH (US health exposure limits):
PEL (Permissible)
 15 mg/m3[1]
REL (Recommended)
 TWA 10 mg/m3 (total) TWA 5 mg/m3 (resp)[1]
IDLH
(Immediate danger)
 N.D.[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Temefos or temephos (trade name Abate) is an

insects[2] including mosquitoes, midges, and black fly larvae
.

As with other organophosphates, temephos affects the central nervous system through inhibition of cholinesterase. In larvae, this results in death before reaching the adult stage.

In the

water fleas
that carry guinea worm larvae.

Resistance to temephos by A. aegypti has been seen in Brazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance in A. aegypti populations from several localities in the country in 1999 (Funasa 2000, Lima et al. 2003). In 1999, mosquitoes from the city of Rio de Janeiro were already resistant to temephos.[4]

References

  1. ^ a b c d e f g NIOSH Pocket Guide to Chemical Hazards. "#0589". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ Abate Product Information
  3. ^ New York Times article covering its application in Africa
  4. PMID 12685640
    .

External links

Bibliography

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