Template:Leucine metabolism in humans

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Diagram of leucine, HMB, and isovaleryl-CoA metabolism in humans
α-Ketoglutarate
Glutamate
Glutamate
Pyruvate
α-Ketoisocaproate
(α-KIC)
α-Ketoisocaproate
(α-KIC)
mitochondria
)
Excreted
in urine
(10–40%)


(
HMG-CoA
lyase
HMG-CoA 
synthase
Unknown
enzyme
β-Hydroxybutyrate
Acetoacetate
Mevalonate
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Human metabolic pathway for HMB and isovaleryl-CoA relative to L-leucine.[3][4][5] Of the two major pathways, L-leucine is mostly metabolized into isovaleryl-CoA, while only about 5% is metabolized into HMB.[3][4][5]