Ternary complex
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A ternary complex is a
substrate; or a complex formed between two proteins and a single substrate.[1] In Immunology
, ternary complex can refer to the MHC–peptide–T-cell-receptor complex formed when T cells recognize epitopes of an antigen.
Another important example is the ternary complex formed during eukaryotic translation, in which ternary complex composed of eIF2 + GTP + Met-tRNAiMet is formed.[2]
A ternary complex can be a complex formed between two substrate molecules and an enzyme. This is seen in multi-substrate enzyme-catalyzed reactions where two substrates and two products can be formed. The ternary complex is an intermediate species in this type of enzyme-catalyzed reaction. An example for a ternary complex is seen in the random-order mechanism or the compulsory-order mechanism of enzyme catalysis for multiple substrates.[3]
The term ternary complex can also refer to a
electrostatic interactions.[4]
References
- ISBN 978-0-12-122725-8.
- PMID 16928960.
- ISSN 0006-2960.
- ISBN 978-3-540-20073-4.
Trevor Palmer (Enzymes, 2nd edition)
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