Anti-tetanus immunoglobulin

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(Redirected from
Tetanus antitoxin
)
Anti-tetanus immunoglobulin
GlaxoSmithKline)
Clinical data
Trade namesHyperTET S/D, others
Other namestetanus immune globulin, tetanus antitoxin
AHFS/Drugs.comMonograph
Routes of
administration		IM
Identifiers
CAS Number
ChemSpider
  • none

Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of

injection into a muscle.[1] Part of the dose is injected at the site of the wound.[2]

Common side effects include pain at the site of injection and fever.

Allergic reactions including anaphylaxis may rarely occur.[1] There is also a very low risk of the spread of infections such as viral hepatitis and HIV/AIDS with the human version.[1] Use during pregnancy and lactation is acceptable.[3][4] It is made from either human or horse blood plasma.[1][5]

The immunoglobulin is categorized as immunoglobulin G (IgG).[4] Since the tetanus toxin permanently binds to human tissues, only unbounded molecules can be neutralized by the immunoglobulin.[2]

Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s.

developed world due to the risk of serum sickness.[9]

References

  1. ^ a b c d e f g h "Tetanus Immune Globulin". The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  2. ^
    PMID 32644434
    , retrieved 2022-08-08
  3. ^ "Tetanus immune globulin Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
  4. ^
    PMID 30000001
    , retrieved 2022-08-08
  5. ^
    ISBN 9780128037089. Archived
    from the original on 2017-01-09.
  6. ISBN 978-1455700905. Archived
    from the original on 2017-01-09.
  7. hdl:10665/325771
    . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. hdl:10665/345533
    . WHO/MHP/HPS/EML/2021.02.
  9. ISBN 9780071641142. Archived
    from the original on 2017-01-09.
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