Therapeutic vaccines

Source: Wikipedia, the free encyclopedia.

A therapeutic vaccine is a

prophylactic
vaccine in that prophylactic vaccines are administered to individuals as a precautionary measure to avoid the infection or disease while therapeutic vaccines are administered after the individual is already affected by the disease or infection. A therapeutic vaccine fights an existing infection in the body rather than immunizing the body for protection against future diseases and infections.[1] Therapeutic vaccines are mostly used against
viral infections. Patients affected with chronic viral infections are administered with therapeutic vaccines, as their immune system is not able to produce enough efficient antibodies.[2]

white blood cells (WBCs) were taken and treated with drug (vaccine) to train them to differentiate and fight cancer cells.[3]

Functionality

Therapeutic vaccines are a new form of vaccines that are mostly being used for viral infections and various types of cancers. A therapeutic vaccine helps an immune system to recognise a foreign agent such as cancerous cells or a virus. The specific type of therapeutic vaccines include antigen vaccines. In case of antigen vaccines, the body is introduced to a foreign agent to activate the immune system so that it recognizes the agent when later encountered.[4]

Types

There are two types of therapeutic vaccines:

Autologous vaccines

Autologous means 'derived from oneself' – an autologous vaccine is a personalized vaccine which is made from an individual's own cells which could be either cancer cells or immune system cells.[5]

Allogeneic vaccines

Allo means 'other'. Allogeneic vaccines are primarily cancer vaccines which are made from a different individual's cancer cells which are grown in a lab.[6]

How therapeutic vaccines differ from prophylactic vaccines

The concept of therapeutic vaccines is different. When a person hears the word vaccine, the thought of prevention against a certain disease comes to mind. However, therapeutic vaccines are a method of treatment. Like any other vaccine, the immune system is regulated against a specific type of target. The main goal is to enhance the immune system activity. This type of vaccine can be employed for the treatment of various type of diseases and viral infections.[7][8] Efforts are being made to develop vaccines against various fatal diseases such as HIV, cancer, dengue fever, cholera, Diphtheria, etc.[citation needed]

Therapeutic vaccines against HIV

HIV has no vaccine up until now, but therapeutic vaccines could be the breakthrough for HIV. Such vaccines would enhance affected patients immune systems to fight the disease. Many researchers are trying to develop and test therapeutic HIV vaccines in order to slow the HIV progression to AIDS. People affected with HIV normally have HIV at undetectable level, which is detected by use of

antiretroviral therapy (ART). If therapeutic vaccines for HIV work out, many lives will be saved.[9] Many clinical trials are being conducted for HIV therapeutic vaccines, such as those conducted by AIDSinfo, summaries for their trials are available at their website.[10]

Therapeutic vaccine against cancer

Cancer is the major cause of deaths in the recent era. Cancer types and stages have enhanced with time and so has efforts to treat cancer. Currently, there are about 369 cancer vaccine studies ongoing all around the world.[11]

There are three cancer therapeutic vaccines which are approved by USA Food and Drug Administration, as following;

Provenge is Sipuleucel-T, a dendritic cell based vaccine for prostate cancer.[12] Bacillus Calmettle-Guerin (TheraCys) is a live attenuated vaccine which makes use of Mycobacterium bovis strain for bladder invasive cancer. Talimogene laherparepvec (T-VEC or Imlygic) is a vaccine for advanced oncolytic melanoma [13]

References

  1. ^ "Preventive vaccine vs therapeutic vaccine | Fondation québecoise du Sida". Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  2. S2CID 107391475
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  4. PMID 20798195.{{cite journal}}: CS1 maint: multiple names: authors list (link
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  7. ^ Griffin, R. Morgan (2006). "Treating Disease With Vaccines". WebMD. Archived from the original on 2021-11-01. Retrieved 2021-04-21.
  8. PMID 18777956.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  9. .
  10. ^ Clinical trial number NCT01103687 for "Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults" at ClinicalTrials.gov
  11. PMID 28857666.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  12. S2CID 12168204.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  13. S2CID 23663167.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )