Thomas C. Südhof
Thomas Südhof | |
---|---|
Born | Thomas Christian Südhof December 22, 1955 |
Nationality | German American[3][4] |
Alma mater | RWTH Aachen University University of Göttingen (PhD) |
Known for | Presynaptic Neuron Synaptic Transmission |
Spouse | Lu Chen |
Awards |
|
Scientific career | |
Fields | Biology |
Institutions | |
Thesis | Die biophysikalische Struktur der chromaffinen Granula im Lichte ihres Osmometerverhaltens und ihrer osmotischen Lyse (1982) |
Doctoral advisor | Victor P. Whittaker |
Website |
Thomas Christian Südhof (German pronunciation:
Südhof, James Rothman and Randy Schekman are the 2013 Nobel Prize in Physiology or Medicine laureates for their work on vesicle trafficking.[6]
Early life and education
A
Career and research
This section of a biography of a living person does not include any references or sources. (December 2021) |
After a brief
During his
In 2008, Südhof moved to Stanford University and is currently the Avram Goldstein Professor in the School of Medicine as well as a Professor of Molecular & Cellular Physiology, Psychiatry, and Neurology.
Südhof laid the foundations for his scientific career studying the synapse early while studying the mechanisms of
After completing his thesis in 1983, Südhof moved to
After finishing postdoctoral training, Südhof started his own laboratory at UT Southwestern in 1986. Briefly continuing work with Goldstein and Brown, Südhof helped identify a DNA element in the LDL gene that produced
Südhof started his independent research career in neuroscience since 1986 and open the field of molecular neuroscience for synaptic transmission especially from the presynaptic nerve terminal perspective. Until Südhof began his work, majority of neuroscience research was aimed at the postsynaptic neuron and its role in learning and memory. Indeed, Thomas Südhof is credited with discovering much of the machinery mediating neurotransmitter release and presynaptic plasticity in his 21 years at UT Southwestern. Südhof began with the discovery of
A second influential contribution of Südhof is on synapse formation and specifications. Südhof discovered a number of key molecules in this process such as
Südhof currently continues his work on synapse formation, maintenance as well as synaptic releases in his laboratory at Stanford University. Additionally, together with Marius Wernig at Stanford University, Südhof developed induced neuronal cell technology where they can use human neuronal cells derived from patients or genetically engineered with defined mutations that linked to neuropsychiatric disorders or neurodevelopmental disorders. Südhof's research has not only given the scientific community a great understanding of the processes underlying synaptic transmission and synapse formation, but has also advanced medical knowledge of mechanisms behind poorly understood diseases such as Alzheimer's, Schizophrenia, and Autism. He is currently working with a diverse group of researchers at the Howard Hughes Medical Institute to develop mouse models for mutants of synaptic genes. The project aims to drastically advance our understanding of neurological disorders. He also serves on the Research Consortium of Cure Alzheimer's Fund.
Südhof recently retracted a 2023 paper from Proceedings of the National Academy of Science after complaints sent to the journal due to "discrepancies between the raw data and the published data".[9]
Science and policy
Südhof recently[when?] also engages in scientific ethics as exemplified by his recent work at PLOS Biology Truth in Science Publishing: A personal Perspective[10] and various interviews including his discussion about music, policy and medicine with The Lancet.[7] In 2017, he published an article in The Washington Post[11] on basic research vs. drug development.
Other activities
In 2023, Südhof was appointed by
Corporate board memberships include:
- Neurocentria, member of the scientific advisory board (since 2023)[13]
- Sanofi, independent member of the board of directors (since 2016)[14]
Awards and honors
- 1993 W. Alden Spencer Award from Columbia University (shared with Richard Scheller)
- 1994 Wilhelm Feldberg Award[15]
- 1997 Roger Eckert Award Lecture, Göttingen[citation needed]
- 1997 U.S. National Academy Award in Molecular Biology (shared with Richard Scheller)
- 2002 Elected to the National Academy of Sciences of the U.S.A.
- 2003 Metlife Foundation Award for Medical Research in Alzheimer's Disease[16] (shared with Roberto Malinow)
- 2004 Bristol-Myers Squibb Awardfor Distinguished Achievement in Neuroscience Research
- 2004 Ulf von Euler Award Lecture, Karolinska Institute
- 2007 Elected to the Institute of Medicine
- 2008 Bernhard Katz Award, Biophysical Society (shared with Reinhard Jahn)
- 2008 Passano Foundation Award
- 2010 Kavli Prize (shared with Richard Scheller and James Rothman)
- 2013 Albert Lasker Award for Basic Medical Research (shared with Richard Scheller)
- 2013 Nobel Prize in Physiology or Medicine - shared with Randy Schekman and James Rothman
- 2014 Golden Plate Award of the American Academy of Achievement[17]
- 2017 Elected a Foreign Member of the Royal Society (ForMemRS)[1]
Personal life
Südhof is married[when?] to Lu Chen, a professor of neurosurgery and of psychiatry and behavioral sciences at Stanford University. The couple have three children.[citation needed] Südhof has four more children from his previous marriage with Annette Südhof.[18]
References
- ^ a b Anon (2017). "Professor Thomas Sudhof ForMemRS". royalsociety.org. Royal Society.
- ^ a b "CAP - Thomas Sudhof". Med.stanford.edu. June 20, 2008. Retrieved October 7, 2013.
- ^ "Ist der Nobelpreisträger Südhof überhaupt Deutscher?". Focus. Retrieved October 7, 2013.
- ^ Medizinnobelpreisträger Thomas Südhof „Ich habe wieder einen deutschen Pass“, Berliner Zeitung, 27 January 2014 (German)
- PMID 20107439.
- ^ "The Nobel Prize in Physiology or Medicine 2013". Nobel Foundation. Retrieved October 7, 2013.
- ^ S2CID 54353897.
- OCLC 916944001.
- ^ www
.thetransmitter .org /retraction /nobel-prize-winner-thomas-sudhof-retracts-study / - PMID 27564858.
- ^ Sudhof, Thomas (2017). "Too many medical trials are moonshots in the dark". washingtonpost.com.
- ^ UN Secretary-General Creates Scientific Advisory Board for Independent Advice on Breakthroughs in Science and Technology United Nations, press release of 3 August 2023.
- ^ Neurocentria announces Dr. Thomas Sudhof to join the Scientific Advisory Board Neurocentria, press release of 12 January 2023.
- ^ Board of Directors Sanofi.
- ^ "Prizewinners of the Feldberg Foundation". Feldberg Foundation. Retrieved April 26, 2018.
- ^ "MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). Archived from the original (PDF) on October 13, 2018.
- American Academy of Achievement.
- ^ "Thomas Südhof Nobel Prize bio note" (PDF) (Press release).
External links
- Thomas C. Südhof on Nobelprize.org