Thymulin

Thymulin
Names
	IUPAC name L-Pyroglutamyl-L-alanyl-L-lysyl-L-seryl-L-glutaminyl-glycyl-glycyl-L-seryl-L-asparagine
Identifiers
CAS Number	63958-90-7 ;
3D model ( JSmol)	Interactive image;
ChemSpider	2342226;
PubChem CID	3085284;
UNII	9H198D04WL ;
CompTox Dashboard (EPA)	DTXSID10213801 ;
	InChI InChI=1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1 Key: LIFNDDBLJFPEAN-BPSSIEEOSA-N;
	SMILES C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@@H]1CCC(=O)N1;
Properties
Chemical formula	C33H54N12O15
Molar mass	858.864 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Thymulin (also known as thymic factor or its old name facteur thymique serique) is a

peptide sequence

is H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH.

The hormone is believed to be involved in

ACTH levels correlate positively with thymulin plasma levels and vice versa^[2]

).

A recent focus has been on the role of thymulin as an effector on proinflammatory mediators/

cytokines. A peptide analog of thymulin (PAT) has been found to have analgesic effects in higher concentrations and particularly neuroprotective anti-inflammatory effects in the CNS.^[3]

Astrocytes seem to be the target for thymulin for this effect. Researchers hope to develop drugs thwarting inflammatory processes associated with neurodegenerative diseases and even rheumatism

with the help of thymulin analogs.

Moreover, thymulin has been associated with anorexia nervosa.^[4]