Tiaprofenic acid

Source: Wikipedia, the free encyclopedia.
Tiaprofenic acid
Clinical data
Trade namesSurgam, Surgamyl, Tiaprofen, others
Other names5-Benzoyl-α-methyl-2-thiopheneacetic acid
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • C
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability90%
Metabolism10% liver
Elimination half-life1.5-2.5h
Excretion50-80% urine
Identifiers
  • (RS)-2-(5-benzoyl-2-thienyl)propanoic acid
JSmol)
ChiralityRacemic mixture
  • O=C(c1sc(cc1)C(C(=O)O)C)c2ccccc2
  • InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17) checkY
  • Key:GUHPRPJDBZHYCJ-UHFFFAOYSA-N checkY
  (verify)

Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended for children.

Long-term use of tiaprofenic acid is associated with severe

cystitis, roughly 100 times more commonly than other NSAIDs.[1] It is contraindicated in patients with cystitis and urinary tract infections. It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine
. Renal disease impairs excretion, and should be used cautiously in renal disease.

It was patented in 1969 and approved for medical use in 1981.[2] It is available in generic formulations. A sustained-release preparation is available. It is an isomer of Suprofen.

References

  1. PMID 9126086
    .
  2. ISBN 9783527607495
    .

External links
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