Timothy Ray Brown

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Timothy Ray Brown
Seattle, Washington, U.S.
DiedSeptember 29, 2020(2020-09-29) (aged 54)
Palm Springs, California, U.S.
NationalityAmerican
Known forFirst person cured of HIV/AIDS

Timothy Ray Brown (March 11, 1966[1] – September 29, 2020) was an American considered to be the first person cured of HIV/AIDS.[2][3] Brown was called "The Berlin Patient" at the 2008 Conference on Retroviruses and Opportunistic Infections, where his cure was first announced, in order to preserve his anonymity. He chose to come forward in 2010. "I didn't want to be the only person cured," he said. "I wanted to do what I could to make [a cure] possible. My first step was releasing my name and image to the public."[4][2][5]

Procedure

Timothy Ray Brown was born in

antiretroviral therapy, researchers could not detect HIV in Brown's blood or in various biopsies.[10] Levels of HIV-specific antibodies in Timothy Brown's blood also declined, suggesting that functional HIV may have been eliminated from his body. However, scientists studying his case warn that this remission of HIV infection is unusual.[11]

Brown, the "Berlin patient", suffered from serious transplant complications, graft-versus-host disease and leukoencephalopathy, which led researchers to conclude that the procedure should not be performed on others with HIV, even if sufficient numbers of suitable donors could be found.[12][13]

Eleven years later, at the same conference, it was announced that it appeared that a second man had been cured. He was called "The London Patient", who later identified himself as

CCR5-Δ32 mutation.[15][5]

As of 2017, six more people also appear to have been cleared of HIV after getting graft-versus-host disease; only one of them had received CCR5 mutant stem cells, leading researchers to conclude that when a transplant recipient has graft-versus-host disease, the transplanted cells may kill off the host's HIV-infected immune cells.[16]

Later life

In July 2012, Brown announced the formation of the Timothy Ray Brown Foundation in Washington, D.C., a foundation dedicated to fighting HIV/AIDS.[17][18]

In September 2020, Brown revealed the leukemia that prompted his historic treatment had returned in 2019 and that he was terminally ill. Brown entered hospice care in Palm Springs, California, where he later died on September 29, 2020.[19] He was 54 years old.

See also

References

  1. ^ a b "Timothy Ray Brown, 'Berlin patient' cured of HIV infection, dies at 54". Washington Post. Retrieved September 30, 2020.
  2. ^
    Fred Hutch. Archived
    from the original on October 16, 2018. Retrieved March 4, 2015.
  3. ^ Trudy Ring (September 7, 2012). "Is Anyone Immune to HIV?". HIVPlusMag. Archived from the original on March 9, 2016. Retrieved January 20, 2015.
  4. ^
    PMID 25328084
    .
  5. ^ a b "berlin patient.pdf" (PDF). Dropbox. Archived (PDF) from the original on September 30, 2020. Retrieved May 8, 2020.
  6. ^ Roberts, Sam (September 30, 2020). "Timothy Ray Brown, First Patient Cured of H.I.V., Dies at 54". The New York Times.
  7. ^ "HIV patient Timothy Brown is the boy who lived". L.A. Times. June 5, 2011. Archived from the original on April 22, 2020. Retrieved September 30, 2020.
  8. ^ "German HIV patient cured after stem cell transplant". Belfast Telegraph. December 15, 2010. Archived from the original on December 22, 2010. Retrieved December 15, 2010.
  9. PMID 16216086. Open access icon
  10. PMID 21148083
    .
  11. ^ "Web Exclusives : Transplanting Hope: Stem Cell Experiment Raises Eyebrows at CROI - by David Evans". Archived from the original on January 26, 2016. Retrieved January 21, 2015.
  12. PMID 19213687. Archived
    from the original on February 15, 2009. Retrieved March 31, 2009.
  13. S2CID 43463970
    .
  14. ^ Davis, Nicola (March 9, 2020). "Second person ever to be cleared of HIV reveals identity". The Guardian. Archived from the original on March 9, 2020. Retrieved March 10, 2020.
  15. ^ Apoorva Mandavilli (March 4, 2019). "H.I.V. Is Reported Cured in a Second Patient, a Milestone in the Global AIDS Epidemic". The New York Times. Archived from the original on May 24, 2019. Retrieved March 4, 2019.
  16. ^ Clare Wilson (May 6, 2017). "Immune war with donor cells after transplant may wipe out HIV". New Scientist. Archived from the original on December 8, 2018. Retrieved May 8, 2017.
  17. ^ "Man "cured" of AIDS: Timothy Ray Brown". CBSNews. Archived from the original on June 12, 2018. Retrieved January 20, 2015.
  18. ^ "Miraculous Activist". The Scientist Magazine®. Archived from the original on August 9, 2020. Retrieved May 8, 2020.
  19. ^ Marilynn Marchione (September 25, 2020). "1st man cured of HIV infection now has terminal cancer". ABC News. Archived from the original on September 30, 2020. Retrieved September 25, 2020.; Mark S. King (September 25, 2020). "As Timothy Ray Brown faces death, a great love endures". Los Angeles Blade. Retrieved September 25, 2020.; "'The Berlin Patient': First person ever cured from HIV infection dies of cancer". www.abc.net.au. September 30, 2020. Archived from the original on September 30, 2020. Retrieved September 30, 2020.

External links

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