Tolnaftate

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Tolnaftate
Clinical data
Trade namesTinactin
Other names2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate[1]
AHFS/Drugs.comMonograph
MedlinePlusa682617
ATC code
Legal status
Legal status
Identifiers
  • O-2-Naphthyl methyl(3-methylphenyl)thiocarbamate
JSmol)
Melting point110 to 111.5 °C (230.0 to 232.7 °F)
  • S=C(Oc2ccc1c(cccc1)c2)N(c3cc(ccc3)C)C
  • InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3 checkY
  • Key:FUSNMLFNXJSCDI-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Tolnaftate (

ringworm.[2]

Mechanism

Although the exact mechanism of action is not entirely known, it is believed to inhibit

squalene epoxidase,[3] an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal cell membrane) in a similar way to terbinafine.[4]

Uses

Tolnaftate has been found to be generally slightly less effective than

ringworm, especially when passed from pets to humans.[5]

Side effects

Side effects that may occur include:[6]

  • allergic reactions like:
    • skin rash
    • itching or hives
    • swelling of the face, lips, or tongue
  • inflammation, redness, or pain at the affected area

Less severe side effects include:[6]

  • dry skin
  • mild skin irritation, burning, or itching at the affected area

See also

References

  1. ^ a b "International Non-Proprietary Names for Pharmaceutical Preparations. Recommended International Non-Proprietary names (Rec. I.N.N.): List 6" (PDF). World Health Organization. Retrieved 12 November 2016.
  2. ^ a b "Tolnaftate". MedlinePlus,gov.
  3. PMID 3524433
    .
  4. ^ "antifung". Archived from the original on 2008-06-17. Retrieved 2008-07-09.
  5. ^ Crawford F, Hart R, Bell-Syer S, Torgerson D, Young P, Russell I. Topical treatments for fungal infections of the skin and nails of the foot (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.
  6. ^ a b "Tolnaftate skin cream, gel, solution, or spray". Cleveland Clinic.

External links

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