Tobacco smoke

Source: Wikipedia, the free encyclopedia.
Tobacco smoke in an Irish pub before a smoking ban came into effect on March 29, 2004

Tobacco smoke is a

fumigant and inhalant
.

Composition

The particles in tobacco smoke are liquid aerosol droplets (about 20% water), with a mass median aerodynamic diameter (MMAD) that is submicrometer (and thus, fairly "lung-respirable" by humans). The droplets are present in high concentrations (some estimates are as high as 1010 droplets per cm3).

Tobacco smoke may be grouped into a particulate phase (trapped on a glass-fiber pad, and termed "TPM" (total particulate matter)) and a gas/vapor phase (which passes through such a glass-fiber pad). "Tar" is mathematically determined by subtracting the weight of the nicotine and water from the TPM. However, several components of tobacco smoke (e.g., hydrogen cyanide, formaldehyde, phenanthrene, and pyrene) do not fit neatly into this rather arbitrary classification, because they are distributed among the solid, liquid and gaseous phases.[1]

Tobacco smoke contains a number of toxicologically significant chemicals and groups of chemicals, including polycyclic aromatic hydrocarbons (benzopyrene), tobacco-specific nitrosamines (NNK, NNN), aldehydes (acrolein, formaldehyde), carbon monoxide, hydrogen cyanide, nitrogen oxides (nitrogen dioxide), benzene, toluene, phenols (phenol, cresol), aromatic amines (nicotine, ABP (4-aminobiphenyl)), and harmala alkaloids. The radioactive element polonium-210 is also known to occur in tobacco smoke.[1] The chemical composition of smoke depends on puff frequency, intensity, volume, and duration at different stages of cigarette consumption.[3]

Between 1933 and the late 1940s, the yields from an average cigarette varied from 33 to 49 mg "tar" and from less than 1 to 3 mg nicotine. In the 1960s and 1970s, the average yield from cigarettes in Western Europe and the USA was around 16 mg tar and 1.5 mg nicotine per cigarette. Current average levels are lower.

wrapping papers.[5] The development of lower "tar" and nicotine cigarettes has tended to yield products that lacked the taste components to which the smoker had become accustomed. In order to keep such products acceptable to the consumer, the manufacturers reconstitute aroma or flavor.[3]

Tobacco

polyphenols (e. g., caffeic acid, chlorogenic acid, scopoletin, rutin) determine the taste and quality of the smoke. Freshly cured tobacco leaf is unfit for use because of its pungent and irritating smoke. After fermentation and aging, the leaf delivers mild and aromatic smoke.[6]

Tumorigenic agents

Tumorigenic agents in tobacco and tobacco smoke
Compounds In processed tobacco, per gram In mainstream smoke, per cigarette IARC evaluation of evidence of carcinogenicity
In laboratory animals In humans
Polycyclic aromatic hydrocarbons
Benz(a)anthracene   20–70 ng sufficient  
Benzo(b)fluoranthene
  4–22 ng sufficient  
Benzo(j)fluoranthene   6–21 ng sufficient  
Benzo(k)fluoranthene   6–12 ng sufficient  
Benzo(a)pyrene 0.1–90 ng 20–40 ng sufficient probable
Chrysene   40–60 ng sufficient  
Dibenz(a,h)anthracene   4 ng sufficient  
Dibenzo(a,i)pyrene
  1.7–3.2 ng sufficient  
Dibenzo(a,l)pyrene
  present sufficient  
Indeno(1,2,3-c,d)pyrene   4–20 ng sufficient  
5-Methylchrysene   0.6 ng sufficient  
Aza-arenes
Quinoline 1–2 μg      
Dibenz(a,h)acridine   0.1 ng sufficient  
Dibenz(a,j)acridine   3–10 ng sufficient  
7H-Dibenzo(c,g)carbazole   0.7 ng sufficient  
N-Nitrosamines
N-Nitrosodimethylamine 0–215 ng 0.1–180 ng sufficient  
N-Nitrosoethylmethylamine   3–13 ng sufficient  
N-Nitrosodiethylamine   0–25 ng sufficient  
N-Nitrosonornicotine 0.3–89 μg 0.12–3.7 μg sufficient  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone 0.2–7 μg 0.08–0.77 μg sufficient  
N-Nitrosoanabasine 0.01–1.9 μg 0.14–4.6 μg limited  
N-Nitrosomorpholine 0–690 ng   sufficient  
Aromatic amines
2-Toluidine
  30–200 ng sufficient inadequate
2-Naphthylamine   1–22 ng sufficient sufficient
4-Aminobiphenyl   2–5 ng sufficient sufficient
Aldehydes
Formaldehyde 1.6–7.4 μg 70–100 μg sufficient  
Acetaldehyde 1.4–7.4 μg 18–1400 μg sufficient  
Crotonaldehyde 0.2–2.4 μg 10–20 μg    
Miscellaneous organic compounds
Benzene   12–48 μg sufficient sufficient
Acrylonitrile   3.2–15 μg sufficient limited
1,1-Dimethylhydrazine
60–147 μg   sufficient  
2-Nitropropane   0.73–1.21 μg sufficient  
Ethyl carbamate 310–375 ng 20–38 ng sufficient  
Vinyl chloride   1–16 ng sufficient sufficient
Inorganic compounds
Hydrazine 14–51 ng 24–43 ng sufficient inadequate
Arsenic 500–900 ng 40–120 ng inadequate sufficient
Nickel 2000–6000 ng 0–600 ng sufficient limited
Chromium 1000–2000 ng 4–70 ng sufficient sufficient
Cadmium 1300–1600 ng 41–62 ng sufficient limited
Lead 8–10 μg 35–85 ng sufficient inadequate
Polonium-210 0.2–1.2 pCi 0.03–1.0 pCi sufficient sufficient

Safety

Tobacco smoke, besides being an

heart disease, chronic obstructive pulmonary disease (COPD), emphysema, and other serious diseases in smokers (and in non-smokers as well). The actual mechanisms by which smoking can cause so many diseases remain largely unknown. Many attempts have been made to produce lung cancer in animals exposed to tobacco smoke by the inhalation route, without success. It is only by collecting the "tar" and repeatedly painting this on to mice that tumors are produced, and these tumors are very different from those tumors exhibited by smokers.[1] Tobacco smoke is associated with an increased risk of developing respiratory conditions such as bronchitis, pneumonia, and asthma. Tobacco smoke aerosols generated at temperatures below 400 °C did not test positive in the Ames assay.[7]

In spite of all changes in cigarette design and manufacturing since the 1960s, the use of filters and "light" cigarettes has neither decreased the nicotine intake per cigarette, nor has it lowered the incidence of lung cancers (

squamous cell cancers has decreased. The change in tumor type is believed to reflect the higher nitrosamine delivery of lower-yield cigarettes and the increased depth or volume of inhalation of lower-yield cigarettes to compensate for lower level concentrations of nicotine in the smoke.[9]

In the United States, lung cancer incidence and mortality rates are particularly high among African American men. Lung cancer tends to be most common in developed countries, particularly in North America and Europe, and less common in developing countries, particularly in Africa and South America.[8][clarification needed]

See also

References

  1. ^
  2. ^ Ken Podraza (29–30 October 2001), Basic Principles of Cigarette Design and Function (PDF), Philip Morris USA
  3. ^ a b The Health Consequences of Smoking: The Changing Cigarette (PDF), U.S. Dept. of Health and Human Services, p. 49
  4. Environmental Health Criteria, World Health Organization
  5. ^ Michael A. H. Russell (1977), "Smoking Problems: An Overview", in Murray E. Jarvik; Joseph W. Cullen; Ellen R. Gritz; Thomas M. Vogt; Louis Jolyon West (eds.), Research on Smoking Behavior (PDF), NIDA Research Monograph, pp. 13–34, archived from the original (PDF) on 2015-07-23
  6. ^